Editing Imidazole (section)

===Formation of four bonds===
This is a general method that is able to give good yields for substituted imidazoles. In essence, it is an adaptation of the Debus method called the [[Debus-Radziszewski imidazole synthesis]]. The starting materials are substituted glyoxal, aldehyde, amine, and ammonia or an ammonium salt.<ref>{{US patent reference|number=6,177,575|y=2001|m=01|d=23|inventor=[[Anthony Joseph Arduengo III|Arduengo, A. J.]]|title=Process for Manufacture of Imidazoles}}</ref>
:[[File:Debus-Radziszewski_imidazole_synthesis.svg|none|500px|Arduengo imidazoles]]