Editing Myeloid sarcoma (section)

== Location and symptoms ==
Chloromas may occur in virtually any organ or tissue. The most common areas of involvement are the skin (also known as ''leukemia cutis'') and the gums. Skin involvement typically appears as violaceous, raised, nontender plaques or nodules, which on [[biopsy]] are found to be infiltrated with myeloblasts<ref name="http://www.ncbi.nlm.nih.gov/pubmed/26063639">
{{cite journal |author=Tan BY. |title=Myeloid Sarcoma Masquerading as Granulation Tissue: A Diagnostic Pitfall. |journal=Int J Surg Pathol |volume=23 |issue=7 |pages=553–556 |year=2015 |doi=10.1177/1066896915588931|pmid=26063639 |s2cid=5658954 }}</ref> Note that leukemia cutis differs from [[Sweet syndrome|Sweet's syndrome]], in which the skin is infiltrated by mature neutrophils in a [[paraneoplastic]] process. Gum involvement ([[Gingival enlargement|gingival hypertrophy]]) leads to swollen, sometimes painful gums which bleed easily with tooth brushing and other minor trauma.

Other tissues which can be involved include [[lymph node]]s, the [[small intestine]], the [[mediastinum]], the [[lung]], [[epidural]] sites, the [[uterus]], the [[ovary|ovaries]], and the orbit of the [[eye]]. Symptoms of chloroma at these sites are related to their anatomic location; chloromas may also be [[asymptomatic]] and be discovered incidentally in the course of evaluation of a person with acute myeloid leukemia.

[[Central nervous system]] involvement, as described above, most often takes the form of ''meningeal leukemia'', or invasion of the [[subarachnoid space]] by leukemic cells. This condition is usually considered separately from chloroma, as it requires different treatment modalities. True chloromas (i.e. solid leukemic tumors) of the central nervous system are exceedingly rare, but have been described.