Editing Normal pressure hydrocephalus (section)

=== Medications ===
No medications are effective for primary NPH. Lasting reductions in ICP have not been demonstrated with [[acetazolamide]].<ref name=":1">{{Cite journal |last1=Miyake |first1=H. |last2=Ohta |first2=T. |last3=Kajimoto |first3=Y. |last4=Deguchi |first4=J. |date=1999-11-15 |title=Diamox ® Challenge Test to Decide Indications for Cerebrospinal Fluid Shunting in Normal Pressure Hydrocephalus |url=http://link.springer.com/10.1007/s007010050417 |journal=Acta Neurochirurgica |volume=141 |issue=11 |pages=1187–1193 |doi=10.1007/s007010050417 |issn=0001-6268 |pmid=10592119 |s2cid=2819074|url-access=subscription }}</ref> Transient reduction in ICP after administration of an [[acetazolamide]] bolus has been shown to be a positive predictor for good response after VP shunt placement in NPH patients.

Research is currently aimed at finding other medication options for the management of NPH symptoms. [[Steroid]]s have demonstrated decreased production of CSF in animal studies on healthy rabbits and dogs, however further testing is required to determine if this is an effective treatment option in humans.<ref name=":3">{{Cite journal |last1=Del Bigio |first1=Marc R. |last2=Di Curzio |first2=Domenico L. |date=2016-02-05 |title=Nonsurgical therapy for hydrocephalus: a comprehensive and critical review |journal=Fluids and Barriers of the CNS |volume=13 |pages=3 |doi=10.1186/s12987-016-0025-2 |doi-access=free |issn=2045-8118 |pmc=4743412 |pmid=26846184}}</ref><ref>{{Cite journal |last1=Lindvall-Axelsson |first1=M. |last2=Hedner |first2=P. |last3=Owman |first3=C. |date=October 1989 |title=Corticosteroid action on choroid plexus: Reduction in Na+?K+-ATPase activity, choline transport capacity, and rate of CSF formation |url=http://link.springer.com/10.1007/BF00249613 |journal=Experimental Brain Research |language=en |volume=77 |issue=3 |pages=605–610 |doi=10.1007/BF00249613 |pmid=2553468 |s2cid=44019348 |issn=0014-4819|url-access=subscription }}</ref><ref>{{Cite journal |last1=Weiss |first1=Martin H. |last2=Nulsen |first2=Frank E. |date=April 1970 |title=The Effect of Glucocorticoids on CSF Flow in Dogs |url=https://thejns.org/view/journals/j-neurosurg/32/4/article-p452.xml |journal=Journal of Neurosurgery |volume=32 |issue=4 |pages=452–458 |doi=10.3171/jns.1970.32.4.0452 |pmid=5417941 |issn=0022-3085|url-access=subscription }}</ref> A trial of [[triamterene]] in adults with chronic hydrocephalus has also shown improvement of symptoms within 12 weeks, however further research is needed to support this as a non-surgical option for NPH.<ref name=":3" />