Editing Pathophysiology (section)

====Germ theory====
By 1863, motivated by [[Louis Pasteur]]'s report on fermentation to [[butyric acid]], fellow Frenchman [[Casimir Davaine]] identified a microorganism as the crucial causal agent of the cattle disease [[anthrax]], but its routinely vanishing from blood left other scientists inferring it a mere byproduct of [[putrefaction]].<ref>{{cite journal | author = Théodoridès J | title = Casimir Davaine (1812-1882): A precursor of Pasteur | journal = Medical History | volume = 10 | issue = 2 | pages = 155–65 | year = 1966 | pmid = 5325873 | pmc = 1033586 | doi = 10.1017/S0025727300010942 }}</ref>  In 1876, upon [[Ferdinand Cohn]]'s report of a tiny spore stage of a bacterial species, the fellow German [[Robert Koch]] isolated Davaine's ''bacterides'' in [[pure culture]] —a pivotal step that would establish [[bacteriology]] as a distinct discipline— identified a spore stage, applied [[Jakob Henle]]'s postulates, and confirmed Davaine's conclusion, a major feat for [[experimental pathology]]. Pasteur and colleagues followed up with [[ecology|ecological]] investigations confirming its role in the natural environment via spores in soil.

Also, as to [[sepsis]], Davaine had injected rabbits with a highly diluted, tiny amount of putrid blood, duplicated disease, and used the term ''ferment of putrefaction'', but it was unclear whether this referred as did Pasteur's term ''ferment'' to a microorganism or, as it did for many others, to a chemical.<ref name=Bulloch143-148>Bulloch, William, [https://books.google.com/books/about/The_history_of_bacteriology.html?id=TQgZAAAAMAAJ ''The History of Bacteriology''] (Oxford: Oxford University Press, 1938 & 1960 / New York: Dover Publications, 1979), p 143–144, 147-148</ref>  In 1878, Koch published ''Aetiology of Traumatic Infective Diseases'', unlike any previous work, where in 80 pages Koch, as noted by a historian, "was able to show, in a manner practically conclusive, that a number of diseases, differing clinically, anatomically, and in [[aetiology]], can be produced experimentally by the injection of putrid materials into animals."<ref name=Bulloch143-148/>  Koch used bacteriology and the new staining methods with [[aniline dye]]s to identify particular microorganisms for each.<ref name=Bulloch143-148/> [[Germ theory of disease]] crystallized the concept of cause—presumably identifiable by scientific investigation.<ref>{{cite journal | author = Carter KC | title = Germ theory, hysteria, and Freud's early work in psychopathology | journal = Medical History | volume = 24 | issue = 3 | pages = 259–74 | year = 1980 | pmid = 6997653 | pmc = 1082654 | doi = 10.1017/S002572730004031X }}</ref>