Editing Peroxisome proliferator-activated receptor (section)

== Pharmacology and PPAR modulators ==
{{main article|PPAR modulator}}
PPARα and PPARγ are the molecular targets of a number of marketed [[drug]]s. 

For instance the [[Hypolipidemic agent|hypolipidemic]] [[fibrate]]s activate PPARα.{{cn|date=March 2023}}

The [[anti-diabetic drugs|anti diabetic]] [[thiazolidinediones]] activate PPARγ.{{cn|date=March 2023}} 

The synthetic chemical [[perfluorooctanoic acid]] activates PPARα while [[perfluorononanoic acid]] activates both PPARα and PPARγ. {{cn|date=March 2023}}

[[Berberine]] inactivates PPARγ.<ref>{{cite journal | vauthors =  Huang C, Zhang Y, Gong Z, Sheng X, Li Z, Zhang W, Qin Y | title =  Berberine inhibits 3T3-L1 adipocyte differentiation through the PPARgamma pathway | journal =  Biochemical and Biophysical Research Communications  | volume = 348 | issue = 2 | pages = 571–578 | year = 2006 | doi =  10.1016/j.bbrc.2006.07.095| pmid = 16890192 }}</ref>

Other natural compounds from different chemical classes activate or inactivate PPARγ.<ref name="pmid23811337">{{cite journal | vauthors = Atanasov AG, Wang JN, Gu SP, Bu J, Kramer MP, Baumgartner L, Fakhrudin N, Ladurner A, Malainer C, Vuorinen A, Noha SM, Schwaiger S, Rollinger JM, Schuster D, Stuppner H, Dirsch VM, Heiss EH | title = Honokiol: a non-adipogenic PPARγ agonist from nature | journal = Biochim. Biophys. Acta | volume = 1830 | issue = 10 | pages = 4813–9 | year = 2013 | pmid = 23811337 | pmc = 3790966 | doi = 10.1016/j.bbagen.2013.06.021 }}</ref><ref name="pmid23630612">{{cite journal | vauthors = Atanasov AG, Blunder M, Fakhrudin N, Liu X, Noha SM, Malainer C, Kramer MP, Cocic A, Kunert O, Schinkovitz A, Heiss EH, Schuster D, Dirsch VM, Bauer R | title = Polyacetylenes from Notopterygium incisum--new selective partial agonists of peroxisome proliferator-activated receptor-gamma | journal = PLOS ONE | volume = 8 | issue = 4 | pages = e61755 | year = 2013 | pmid = 23630612 | pmc = 3632601 | doi = 10.1371/journal.pone.0061755 | bibcode = 2013PLoSO...861755A | doi-access = free }}</ref><ref>{{Cite journal |last1=Ammazzalorso |first1=Alessandra |last2=Amoroso |first2=Rosa |date=2019-02-28 |title=Inhibition of PPARγ by Natural Compounds as a Promising Strategy in Obesity and Diabetes |url=https://openmedicinalchemistryjournal.com/VOLUME/13/PAGE/7/FULLTEXT/ |journal=The Open Medicinal Chemistry Journal |language=en |volume=13 |issue=1 |pages=7–15 |doi=10.2174/1874104501913010007|doi-access=free }}</ref>