Editing Platelet (section)

===Adhesion===
[[Thrombus]] formation on an intact [[endothelium]] is prevented by [[nitric oxide]],<ref>{{cite journal |vauthors=Palmer RM, Ferrige AG, Moncada S |title=Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor |journal=Nature |volume=327 |issue=6122 |pages=524–6 |date=1987 |pmid=3495737 |doi=10.1038/327524a0 |bibcode=1987Natur.327..524P |s2cid=4305207}}</ref> [[prostacyclin]],<ref name="Jones-2012">{{cite book <!-- Citation bot bypass-->|vauthors=Jones CI, Barrett NE, Moraes LA, Gibbins JM, Jackson DE |chapter=Endogenous inhibitory mechanisms and the regulation of platelet function |volume=788 |pages=341–366 |date=2012 |pmid=22130718 |doi=10.1007/978-1-61779-307-3_23 |isbn=978-1-61779-306-6 |series=Methods in Molecular Biology |title=Platelets and Megakaryocytes }}</ref> and [[CD39]].<ref>{{cite journal |vauthors=Marcus AJ, Broekman MJ, Drosopoulos JH, Olson KE, Islam N, Pinsky DJ, Levi R |title=Role of CD39 (NTPDase-1) in thromboregulation, cerebroprotection, and cardioprotection |journal=Seminars in Thrombosis and Hemostasis |volume=31 |issue=2 |pages=234–246 |date=April 2005 |pmid=15852226 |doi=10.1055/s-2005-869528|s2cid=41764516 }}</ref>

[[Endothelial cells]] attach to the subendothelial [[collagen]] by [[von Willebrand factor]] (VWF), which these cells produce. VWF is also stored in the [[Weibel-Palade bodies]] of the endothelial cells and secreted constitutively into the blood. Platelets store vWF in their alpha granules.

When the endothelial layer is disrupted, collagen and VWF anchor platelets to the subendothelium. Platelet [[glycoprotein Ib-IX-V Receptor Complex|GP1b-IX-V]] receptor binds with VWF; and GPVI receptor and integrin α2β1 bind with collagen.<ref name=Dubois06>{{cite journal |vauthors=Dubois C, Panicot-Dubois L, Merrill-Skoloff G, Furie B, Furie BC |title=Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivo |journal=Blood |volume=107 |issue=10 |pages=3902–6 |date=May 2006 |pmid=16455953 |pmc=1895285 |doi=10.1182/blood-2005-09-3687}}</ref>