Editing Platelet-derived growth factor (section)

== Research ==

Like many other growth factors that have been linked to disease, PDGF and its receptors have provided a market for [[receptor antagonist]]s to treat disease. Such antagonists include (but are not limited to) specific [[antibody|antibodies]] that target the [[molecule]] of interest, which act only in a neutralizing manner.<ref name="pmid9211881">{{cite journal |vauthors=Shulman T, Sauer FG, Jackman RM, Chang CN, Landolfi NF | title = An antibody reactive with domain 4 of the platelet-derived growth factor beta receptor allows BB binding while inhibiting proliferation by impairing receptor dimerization | journal = J. Biol. Chem. | volume = 272 | issue = 28 | pages = 17400–17404 | date = July 1997 | pmid = 9211881 | doi = 10.1074/jbc.272.28.17400 | doi-access = free }}</ref>

The "c-Sis" [[oncogene]] is derived from PDGF.<ref name="ReferenceA"/><ref>{{cite journal |vauthors=McClintock JT, Chan IJ, Thaker SR, Katial A, Taub FE, Aotaki-Keen AE, Hjelmeland LM | title = Detection of c-sis proto-oncogene transcripts by direct enzyme-labeled cDNA probes and in situ hybridization | journal = In Vitro Cell Dev Biol | volume = 28A | issue = 2 | pages = 102–108 | year = 1992 | pmid = 1537750 | doi = 10.1007/BF02631013 | s2cid = 9958016 }}</ref>

Age related downregulation of the PDGF receptor on islet beta cells has been demonstrated to prevent islet beta cell proliferation in both animal and human cells and its re-expression triggered beta cell proliferation and corrected glucose regulation via insulin secretion.<ref>{{cite web|url=http://www.eurekalert.org/pub_releases/2011-10/jdrf-rmo101211.php |title=Researchers make older beta cells act young again |publisher=Eurekalert.org |date=2011-10-12 |access-date=2013-12-28}}</ref><ref>{{cite web |url=http://med.stanford.edu/ism/2011/october/kim.html |title=New Stanford molecular target for diabetes treatment discovered |publisher=Med.stanford.edu – Stanford University School of Medicine |date=2011-10-12 |access-date=2013-12-28 |url-status=dead |archive-url=https://web.archive.org/web/20131021184626/http://med.stanford.edu/ism/2011/october/kim.html |archive-date=2013-10-21 }}</ref>

A non-viral PDGF "bio patch" can regenerate missing or damaged bone by delivering DNA in a nano-sized particle directly into cells via genes. Repairing bone fractures, fixing craniofacial defects and improving dental implants are among potential uses. The patch employs a collagen platform seeded with particles containing the genes needed for producing bone. In experiments, new bone fully covered skull wounds in test animals and stimulated growth in human bone marrow [[stromal cell]]s.<ref>{{cite journal|url=http://www.kurzweilai.net/bio-patch-can-regrow-bone-for-dental-implants-and-craniofacial-defects |title=Bio patch can regrow bone for dental implants and craniofacial defects |journal=Biomaterials |volume=35 |issue=2 |pages=737–747 |doi=10.1016/j.biomaterials.2013.10.021 |pmid=24161167 |pmc=3855224 |publisher=KurzweilAI |date=2013-11-12 |access-date=2013-12-28|last1=Elangovan |first1=S. |last2=d'Mello |first2=S. R. |last3=Hong |first3=L. |last4=Ross |first4=R. D. |last5=Allamargot |first5=C. |last6=Dawson |first6=D. V. |last7=Stanford |first7=C. M. |last8=Johnson |first8=G. K. |last9=Sumner |first9=D. R. |last10=Salem |first10=A. K. }}</ref><ref>{{cite journal |vauthors=Elangovan S, D'Mello SR, Hong L, Ross RD, Allamargot C, Dawson DV, Stanford CM, Johnson GK, Sumner DR, Salem AK | title = The enhancement of bone regeneration by gene activated matrix encoding for platelet derived growth factor | journal = Biomaterials | volume = 35 | issue = 2 | pages = 737–747 | year = 2014 | pmid = 24161167 | pmc = 3855224 | doi = 10.1016/j.biomaterials.2013.10.021 }}</ref>

The addition of PDGF at specific time‐points has been shown to stabilise vasculature in collagen‐[[glycosaminoglycan]] scaffolds.<ref>{{cite journal |last1=Amaral |first1=Ronaldo Jose Farias Correa |last2=Cavanagh |first2=Brenton |last3=O'Brien |first3=Fergal Joseph |last4=Kearney |first4=Cathal John |title=Platelet-derived growth factor stabilises vascularisation in collagen-glycosaminoglycan scaffolds |journal=Journal of Tissue Engineering and Regenerative Medicine |volume=13 |issue=2 |pages=261–273 |date=16 December 2018 |doi=10.1002/term.2789|pmid=30554484 |s2cid=58767660 |url=https://figshare.com/articles/journal_contribution/10765319 |doi-access=free |url-access=subscription }}</ref>