Editing Protein structure (section)

===Homomers===

An assemblage of multiple copies of a particular [[polypeptide]] chain can be described as a [[homomeric|homomer]], [[multimer]] or [[oligomer]].  Bertolini et al. in 2021<ref name = Bertolini2021>{{cite journal |vauthors=Bertolini M, Fenzl K, Kats I, Wruck F, Tippmann F, Schmitt J, Auburger JJ, Tans S, Bukau B, Kramer G |title=Interactions between nascent proteins translated by adjacent ribosomes drive homomer assembly |journal=Science |volume=371 |issue=6524 |pages=57–64 |date=January 2021 |pmid=33384371 |pmc=7613021 |doi=10.1126/science.abc7151 |bibcode=2021Sci...371...57B |url=}}</ref> presented evidence that homomer formation may be driven by interaction between nascent polypeptide chains as they are translated from [[messenger RNA|mRNA]] by nearby adjacent [[ribosome]]s.  Hundreds of proteins have been identified as being assembled into homomers in human cells.<ref name = Bertolini2021/>  The process of assembly is often initiated by the interaction of the N-terminal region of polypeptide chains. Evidence that numerous gene products form homomers (multimers) in a variety of organisms based on [[complementation (genetics)|intragenic complementation]] evidence was reviewed in 1965.<ref>{{cite journal |vauthors=BERNSTEIN H, EDGAR RS, DENHARDT GH |title=Intragenic Complementation Among Temperature Sensitive Mutants of Bacteriophage T4D |journal=Genetics |volume=51 |issue=6 |pages=987–1002 |date=June 1965 |pmid=14337770 |pmc=1210828 |doi=10.1093/genetics/51.6.987 |url=}}</ref>