Editing Pyrethroid (section)

===Humans===
Pyrethroid absorption can happen via skin, inhalation or ingestion.<ref name=":0">{{Cite journal|last1=Bradberry|first1=Sally M.|last2=Cage|first2=Sarah A.|last3=Proudfoot|first3=Alex T.|last4=Vale|first4=J. Allister|date=2005|title=Poisoning due to pyrethroids|journal=[[Toxicological Reviews]]|volume=24|issue=2|pages=93–106|doi=10.2165/00139709-200524020-00003|issn=1176-2551|pmid=16180929|s2cid=32523158}}</ref> Pyrethroids often do not bind efficiently to mammalian [[sodium channel]]s.<ref>{{Cite journal|display-authors=etal|vauthors=Silver KS|date=2014|title=Voltage-gated sodium channels as insecticide targets|journal=[[Advances in Insect Physiology]]|volume=46|pages=389–433|doi=10.1016/B978-0-12-417010-0.00005-7|pmc=6005695|pmid=29928068|isbn=9780124170100}}</ref> They also absorb poorly via skin and human liver is often able to metabolize them relatively efficiently. Pyrethroids are thus much less toxic to humans than to insects.<ref>{{Cite journal|last1=Ray|first1=David E.|last2=Ray|first2=Dr David|last3=Forshaw|first3=Philip J.|date=2000-01-01|title=Pyrethroid Insecticides: Poisoning Syndromes, Synergies, and Therapy|journal=[[Journal of Toxicology: Clinical Toxicology]]|volume=38|issue=2|pages=95–101|doi=10.1081/CLT-100100922|issn=0731-3810|pmid=10778904|s2cid=22213256}}</ref> 

It is not well established if chronic exposure to small amounts of pyrethroids is hazardous or not.<ref>{{Cite journal|last1=Burns|first1=C|last2=Pastoor|first2=T|date=2018|title=Pyrethroid epidemiology: a quality-based review|journal=[[Critical Reviews in Toxicology]]|volume=48|issue=4|pages=297–311|doi=10.1080/10408444.2017.1423463|pmid=29389244|doi-access=free}}</ref> However, large doses can cause acute poisoning, which is rarely life threatening. Typical symptoms include facial [[paresthesia]], itching, burning, dizziness, nausea, vomiting and more severe cases of muscle twitching. Severe poisoning is often caused by ingestion of pyrethroids and can result in a variety of symptoms like seizures, [[coma]], bleeding or [[pulmonary edema]].<ref name=":0" /> There is an association of pyrethroids with poorer early social-emotional and language development.<ref name=VHEMBE />