Editing Recurrent miscarriage (section)

=== Endocrine disorders ===

Women with [[hypothyroidism]] are at increased risk for pregnancy losses. Unrecognized or poorly treated [[diabetes mellitus]] leads to increased miscarriages. Women with [[polycystic ovary syndrome]] also have higher loss rates possibly related to hyperinsulinemia or excess androgens. Inadequate production of [[progesterone]] in the luteal phase may set the stage for RPL.

* '''Luteal phase defect:''' The issue of a [[luteal phase defect]] is complex. The theory behind the concept suggests that an inadequate amount of [[progesterone]] is produced by the [[corpus luteum]] to maintain the early pregnancy. Assessment of this situation was traditionally carried out by an [[endometrial biopsy]], however recent studies have not confirmed that such assessment is valid.<ref name="ACOG2001" /> Studies about the value of progesterone supplementation remain deficient, however, such supplementation is commonly carried out on an empirical basis.{{citation needed|date=June 2016}}