Editing Streptococcus pyogenes (section)

=== Genome ===
The genomes of different strains were sequenced (genome size is 1.8–1.9 Mbp),<ref>{{cite journal | vauthors = Beres SB, Richter EW, Nagiec MJ, Sumby P, Porcella SF, DeLeo FR, Musser JM | title = Molecular genetic anatomy of inter- and intraserotype variation in the human bacterial pathogen group A Streptococcus | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 18 | pages = 7059–7064 | date = May 2006 | pmid = 16636287 | pmc = 1459018 | doi = 10.1073/pnas.0510279103 | doi-access = free | bibcode = 2006PNAS..103.7059B }}</ref> encoding about 1700-1900 proteins (1700 in strain NZ131,<ref>{{cite web|url=http://microbesonline.org/cgi-bin/genomeInfo.cgi?tId=471876|title=Streptococcus pyogenes NZ131}}</ref><ref name="McShan2008">{{cite journal | vauthors = McShan WM, Ferretti JJ, Karasawa T, Suvorov AN, Lin S, Qin B, Jia H, Kenton S, Najar F, Wu H, Scott J, Roe BA, Savic DJ | display-authors = 6 | title = Genome sequence of a nephritogenic and highly transformable M49 strain of Streptococcus pyogenes | journal = Journal of Bacteriology | volume = 190 | issue = 23 | pages = 7773–7785 | date = December 2008 | pmid = 18820018 | pmc = 2583620 | doi = 10.1128/JB.00672-08 }}</ref> 1865 in strain MGAS5005<ref name="Sumby">{{cite journal | vauthors = Sumby P, Porcella SF, Madrigal AG, Barbian KD, Virtaneva K, Ricklefs SM, Sturdevant DE, Graham MR, Vuopio-Varkila J, Hoe NP, Musser JM | display-authors = 6 | title = Evolutionary origin and emergence of a highly successful clone of serotype M1 group a Streptococcus involved multiple horizontal gene transfer events | journal = The Journal of Infectious Diseases | volume = 192 | issue = 5 | pages = 771–782 | date = September 2005 | pmid = 16088826 | doi = 10.1086/432514 | doi-access = free }}</ref><ref>{{cite web|url=http://microbesonline.org/cgi-bin/genomeInfo.cgi?tId=293653|title=Streptococcus pyogenes MGAS5005}}</ref>). Complete genome sequences of the type strain of ''S. pyogenes'' ([https://www.phe-culturecollections.org.uk/products/bacteria/detail.jsp?refId=NCTC+8198&collection=nctc NCTC 8198<sup>T</sup>] = [https://ccug.se/strain?id=4207&s=0&p=1&sort=rel&collection=entire&records=25&t=4207 CCUG 4207<sup>T</sup>]) are available in [[DNA Data Bank of Japan]], [[European Nucleotide Archive]], and [[GenBank]] under the accession numbers [https://www.ncbi.nlm.nih.gov/nuccore/NZ_LN831034.1 LN831034] and [https://www.ncbi.nlm.nih.gov/nuccore/NZ_CP028841.1 CP028841].<ref>{{cite journal | vauthors = Salvà-Serra F, Jaén-Luchoro D, Jakobsson HE, Gonzales-Siles L, Karlsson R, Busquets A, Gomila M, Bennasar-Figueras A, Russell JE, Fazal MA, Alexander S, Moore ER | display-authors = 6 | title = Complete genome sequences of Streptococcus pyogenes type strain reveal 100%-match between PacBio-solo and Illumina-Oxford Nanopore hybrid assemblies | journal = Scientific Reports | volume = 10 | issue = 1 | pages = 11656 | date = July 2020 | pmid = 32669560 | pmc = 7363880 | doi = 10.1038/s41598-020-68249-y }}</ref>