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===Contemporary=== {{See also|Tobacco control|Tobacco in the United States}} Following the scientific revelations of the mid-20th century, tobacco was condemned as a health hazard, and eventually became recognized as a cause of cancer, as well as other respiratory and circulatory diseases. In the [[United States]], this led to the adoption of the 1998 [[Tobacco Master Settlement Agreement]], which settled the many lawsuits by the U.S. states in exchange for a combination of yearly payments to the states and voluntary restrictions on advertising and marketing of tobacco products.<ref>{{cite journal |last1=Schroeder |first1=Steven A. |title=Tobacco Control in the Wake of the 1998 Master Settlement Agreement |journal=New England Journal of Medicine |date=15 January 2004 |volume=350 |issue=3 |pages=293β301 |doi=10.1056/NEJMsr031421 |pmid=14715919 |doi-access=free }}</ref> In the 1970s, [[Brown & Williamson]] cross-bred a strain of tobacco to produce [[Y1 (tobacco)|Y1]], a strain containing an unusually high nicotine content, nearly doubling from 3.2β3.5% to 6.5%. In the 1990s, this prompted the [[Food and Drug Administration]] to allege that [[tobacco industry|tobacco companies]] were intentionally manipulating the nicotine content of [[cigarette]]s.<ref>{{Cite web |title=Interviews β Dr. David Kessler {{!}} Inside The Tobacco Deal {{!}} Frontline {{!}} PBS |url=https://www.pbs.org/wgbh/pages/frontline/shows/settlement/interviews/kessler.html |access-date=2023-04-20 |website=www.pbs.org}}</ref> The desire of many addicted smokers to quit has led to the development of [[nicotine replacement therapy|tobacco cessation products]].<ref>{{Cite journal|last=Commissioner|first=Office of the|date=September 9, 2020|title=Want to Quit Smoking? FDA-Approved Products Can Help|url=https://www.fda.gov/consumers/consumer-updates/want-quit-smoking-fda-approved-products-can-help|archive-url=https://web.archive.org/web/20190427202103/https://www.fda.gov/consumers/consumer-updates/want-quit-smoking-fda-approved-products-can-help|url-status=dead|archive-date=April 27, 2019|journal=FDA|language=en}}</ref> In 2003, in response to growth of tobacco use in developing countries, the [[World Health Organization]]<ref>{{cite web|url=https://www.who.int/fctc/en/index.html|archive-url=https://web.archive.org/web/20080527122132/http://www.who.int/fctc/en/index.html|url-status=dead|archive-date=May 27, 2008|title=WHO | WHO Framework Convention on Tobacco Control (WHO FCTC)|publisher=Who.int|access-date=September 18, 2008}}</ref> successfully rallied 168 countries to sign the [[WHO Framework Convention on Tobacco Control|Framework Convention on Tobacco Control]]. The convention is designed to push for effective legislation and enforcement in all countries to reduce the harmful effects of tobacco.<ref>{{cite web|title=WHO {{!}} WHO Framework Convention on Tobacco Control|url=http://www.who.int/fctc/text_download/en/|access-date=February 17, 2021|publisher=WHO}}</ref> Between 2019 and 2021, concerns about increased COVID-19 health risks due to tobacco consumption facilitated smoking reduction and cessation.<ref>{{cite journal |last1=Yang |first1=Haiyang |last2=Ma |first2=Jingjing |title=How the COVID-19 pandemic impacts tobacco addiction: Changes in smoking behavior and associations with well-being |journal=Addictive Behaviors |date=August 2021 |volume=119 |pages=106917 |doi=10.1016/j.addbeh.2021.106917 |doi-access=free |pmid=33862579 |pmc=9186053 }}</ref>
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