Editing Transdifferentiation (section)

=== Initial epigenetic activation phase approach ===

Somatic cells are first transfected with pluripotent reprogramming factors temporarily ([[Oct4]], [[Sox2]], [[Homeobox protein NANOG|Nanog]], etc.) before being transfected with the desired inhibitory or activating factors.<ref>{{Cite journal 
| last1 = Efe | first1 = J. A. 
| last2 = Hilcove | first2 = S. 
| last3 = Kim | first3 = J. 
| last4 = Zhou | first4 = H. 
| last5 = Ouyang | first5 = K. 
| last6 = Wang | first6 = G. 
| last7 = Chen | first7 = J. 
| last8 = Ding | first8 = S. 
| doi = 10.1038/ncb2164 
| title = Conversion of mouse fibroblasts into cardiomyocytes using a direct reprogramming strategy 
| journal = Nature Cell Biology 
| volume = 13 
| issue = 3 
| pages = 215–222 
| year = 2011 
| pmid = 21278734 
| s2cid = 5310172 
}}</ref> Here is a list of [[Examples of in vitro transdifferentiation by initial epigenetic activation phase approach|examples in vitro]].