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Transient receptor potential channel
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===TRPN=== {| class="wikitable" !Family !Sub-Family !Known Taxa<ref name="Schuler">{{cite journal | vauthors = Schüler A, Schmitz G, Reft A, Özbek S, Thurm U, Bornberg-Bauer E | title = The Rise and Fall of TRP-N, an Ancient Family of Mechanogated Ion Channels, in Metazoa | journal = Genome Biology and Evolution | volume = 7 | issue = 6 | pages = 1713–27 | date = June 2015 | pmid = 26100409 | pmc = 4494053 | doi = 10.1093/gbe/evv091 }}</ref><ref name="Peng" /> |- |TRPN |TRPN/nompC |Placozoans, cnidarians, nematodes, arthropods, molluscs, [[annelids]], and vertebrates (excluding amniotes) |} TRPN was originally described in ''Drosophila melanogaster'' and ''Caenorhabditis elegans'' as nompC, a mechanically gated ion channel.<ref>{{cite journal | vauthors = Walker RG, Willingham AT, Zuker CS | title = A Drosophila mechanosensory transduction channel | journal = Science | volume = 287 | issue = 5461 | pages = 2229–34 | date = March 2000 | pmid = 10744543 | doi = 10.1126/science.287.5461.2229 | bibcode = 2000Sci...287.2229W }}</ref><ref name="Schuler" /> Only a single TRPN, N for "no mechanoreceptor potential C," or "nompC", is known to be broadly expressed in animals (although some Cnidarians have more), and is notably only a [[pseudogene]] in [[amniote]] vertebrates.<ref name="Schuler" /><ref name="Peng" /> Despite TRPA being named for ankyrin repeats, TRPN channels are thought to have the most of any TRP channel, typically around 28, which are highly conserved across taxa <ref name="Schuler" /> Since its discovery, ''Drosophila'' nompC has been implicated in mechanosensation (including mechanical stimulation of the cuticle and sound detection) and cold [[nociception]].<ref name="Himmel_InvNoc">{{cite book | vauthors =Himmel N, Patel A, Cox D | chapter = Invertebrate Nociception | title = The Oxford Research Encyclopedia of Neuroscience |date=March 2017 |doi=10.1093/acrefore/9780190264086.013.166 |isbn=9780190264086 }}</ref>
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