Editing Weakness (section)

====Central fatigue====
The central fatigue is generally described in terms of a reduction in the [[nervous system|neural]] drive or nerve-based motor command to working muscles that results in a decline in the force output.<ref>{{cite journal |author=Gandevia SC |title=Spinal and supraspinal factors in human muscle fatigue |journal=Physiol. Rev. |volume=81 |issue=4 |pages=1725–89 |year=2001 |pmid=11581501 |doi=10.1152/physrev.2001.81.4.1725 }}</ref><ref>{{cite journal |vauthors=Kay D, Marino FE, Cannon J, St Clair Gibson A, Lambert MI, Noakes TD |title=Evidence for neuromuscular fatigue during high-intensity cycling in warm, humid conditions |journal=Eur. J. Appl. Physiol. |volume=84 |issue=1–2 |pages=115–21 |year=2001 |pmid=11394239 |doi=10.1007/s004210000340|s2cid=25906759 }}</ref><ref>{{cite journal |doi=10.3109/13813459109145909 |vauthors=Vandewalle H, Maton B, Le Bozec S, Guerenbourg G |title=An electromyographic study of an all-out exercise on a cycle ergometer |journal=Archives Internationales de Physiologie, de Biochimie et de Biophysique |volume=99 |issue=1 |pages=89–93 |year=1991 |pmid=1713492 }}</ref>  It has been suggested that the reduced neural drive during exercise may be a protective mechanism to prevent organ failure if the work was continued at the same intensity.<ref>{{cite journal |vauthors=Bigland-Ritchie B, Woods JJ |title=Changes in muscle contractile properties and neural control during human muscular fatigue |journal=Muscle Nerve |volume=7 |issue=9 |pages=691–9 |year=1984 |pmid=6100456 |doi=10.1002/mus.880070902|s2cid=13606531 }}</ref><ref>{{cite journal |author=Noakes TD |title=Physiological models to understand exercise fatigue and the adaptations that predict or enhance athletic performance |journal=Scandinavian Journal of Medicine & Science in Sports |volume=10 |issue=3 |pages=123–45 |year=2000 |pmid=10843507 |doi=10.1034/j.1600-0838.2000.010003123.x|s2cid=23103331 }}</ref> The exact mechanisms of central fatigue are unknown, though there has been considerable interest in the role of [[serotonin|serotonergic]] pathways.<ref>{{cite journal |author=Davis JM |title=Carbohydrates, branched-chain amino acids, and endurance: the central fatigue hypothesis |journal=International Journal of Sport Nutrition |volume=5 |issue=Suppl |pages=S29–38 |year=1995 |pmid=7550256 |doi=10.1123/ijsn.5.s1.s29 }}</ref><ref>Newsholme, E. A., Acworth, I. N., & Blomstrand, E. 1987, 'Amino acids, brain neurotransmitters and a functional link between muscle and brain that is important in sustained exercise', in  G Benzi (ed.), Advances in Myochemistry, Libbey Eurotext, London, pp. 127-133.</ref><ref>{{cite book |vauthors=Newsholme EA, Blomstrand E |chapter=Tryptophan, 5-Hydroxytryptamine and a Possible Explanation for Central Fatigue |title=Fatigue |volume=384 |pages=315–20 |year=1995 |pmid=8585461 |doi=10.1007/978-1-4899-1016-5_25|series=Advances in Experimental Medicine and Biology |isbn=978-1-4899-1018-9 }}</ref>