Editing 2C-B (section)

==Side effects==
* Some users report mild "jitters" (body tremors), shuddering breath, and/or mild muscle spasms after insufflating 2C-B. Whether or not these effects are enjoyable depends on the user;
* Mild to intense diarrhea, gas, nausea, and general gastrointestinal discomfort;
* Severe headaches after coming down from large doses have been reported. However, many users report a lack of "comedown" or "crash", instead noting a gradual return to sobriety;
* At doses over 30–40&nbsp;mg the user may experience frightening [[hallucination]]s, as well as [[tachycardia]], [[hypertension]], and [[hyperthermia]];<ref name="CarmoHengstlerdeBoer2005">{{cite journal | vauthors = Carmo H, Hengstler JG, de Boer D, Ringel M, Remião F, Carvalho F, Fernandes E, dos Reys LA, Oesch F, de Lourdes Bastos M | title = Metabolic pathways of 4-bromo-2,5-dimethoxyphenethylamine (2C-B): analysis of phase I metabolism with hepatocytes of six species including human | journal = Toxicology | volume = 206 | issue = 1 | pages = 75–89 | date = January 2005 | pmid = 15590110 | doi = 10.1016/j.tox.2004.07.004 | bibcode = 2005Toxgy.206...75C | url = https://www.erowid.org/references/refs_view.php?A=ShowDocPartFrame&C=ref&ID=7928&DocPartID=7021 | url-access = subscription }}</ref>
* 2C-B HCl is very painful to insufflate. Anecdotal evidence suggests that 2C-B HBr, the [[hydrobromide]] salt with greater water solubility, is less irritating to the mucous membranes lining the nose but slightly less potent when compared dose-for-dose with the HCl salt;<ref>{{cite web|url=https://erowid.org/chemicals/2cb/2cb_faq.shtml|title=Erowid 2C-B Vault : FAQ v1.0 |website=erowid.org}}</ref>
* Rectal administration of a water-based solution of 2C-B is known to be less painful than insufflation and much more potent than oral administration.

Severe adverse reactions are rare, but use of 2C-B was linked to significant brain injury in one case report; the alleged "2C-B" was never actually discovered by testing so the only evidence suggesting 2C-B was the cause was the victim's own words, without taking into consideration that adulteration and impurities are very common in illicit drugs.<ref name="pmid20445431">{{cite journal |vauthors=Ambrose JB, Bennett HD, Lee HS, Josephson SA |date=May 2010 |title=Cerebral vasculopathy after 4-bromo-2,5-dimethoxyphenethylamine ingestion |journal=The Neurologist |volume=16 |issue=3 |pages=199–202 |doi=10.1097/NRL.0b013e3181a3cb53 |pmid=20445431 |s2cid=35035721}}</ref> There is a [[case report]] of acquired [[synesthesia]] following a single very high dose of 2C-B.<ref name="YanakievaLukeJansari2019">{{cite journal | vauthors = Yanakieva S, Luke DP, Jansari A, Terhune DB | title = Acquired synaesthesia following 2C-B use | journal = Psychopharmacology (Berl) | volume = 236 | issue = 7 | pages = 2287–2289 | date = July 2019 | pmid = 31025060 | doi = 10.1007/s00213-019-05242-y | url = }}</ref> There is also a case report of persistent [[psychosis]] following a single dose of 2C-B.<ref name="HuangBai2011">{{cite journal | vauthors = Huang HH, Bai YM | title = Persistent psychosis after ingestion of a single tablet of '2C-B' | journal = Prog Neuropsychopharmacol Biol Psychiatry | volume = 35 | issue = 1 | pages = 293–294 | date = January 2011 | pmid = 21036198 | doi = 10.1016/j.pnpbp.2010.10.018 | url = }}</ref>