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Australian funnel-web spider
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===Symptoms=== Envenomation symptoms observed following bites by these spiders are very similar. The bite is initially very painful, due to the size of the fangs penetrating the skin.<ref name="lancet"/> Puncture marks and local bleeding are also usually visible. If substantial envenomation occurs, symptoms generally occur within minutes and progress rapidly. Early symptoms of systemic envenomation include [[goose bumps]], [[Perspiration|sweating]], [[Paresthesia|tingling around the mouth and tongue]], [[Fasciculation|twitching]] (initially facial and [[Intercostal muscle|intercostal]]), salivation, [[Lacrimation|watery eyes]], [[Tachycardia|elevated heart rate]], and [[Hypertension|elevated blood pressure]]. As systemic envenomation progresses, symptoms include [[nausea]], [[vomiting]], [[dyspnoea|shortness of breath]] (caused by airway obstruction), [[Psychomotor agitation|agitation]], [[confusion]], writhing, grimacing, [[muscle spasm]]s, [[pulmonary oedema]] (of [[neurogenic]] or hypertensive origin), [[metabolic acidosis]], and extreme hypertension. The final stages of severe envenomation include [[Mydriasis|dilation of the pupils]] (often [[Blown pupil|fixed]]), uncontrolled generalised muscle twitching, [[unconsciousness]], elevated [[intracranial pressure]], and death. Death generally is a result of progressive [[hypotension]] or possibly elevated intracranial pressure consequent on [[cerebral oedema]].<ref name="MJA2005-Isbister"/><ref name="UoS">[https://web.archive.org/web/20110228150754/http://www.anaes.med.usyd.edu.au/venom/spiders.html Australian Spider and Insect Bites]; [[University of Sydney]]</ref><ref>{{cite journal |vauthors=Torda T, Loong E, Greaves I | title = Severe lung oedema and fatal consumption coagulopathy after funnel-web bite | journal = Med J Aust | volume = 2 | issue = #8 | pages = 442β4 | year = 1980 | pmid = 7010098| doi = 10.5694/j.1326-5377.1980.tb131914.x | s2cid = 20647927 }}</ref> The onset of severe envenomation can be rapid. In one prospective study, the median time to onset of envenomation was 28 minutes, with only two cases having onset after two hours (both had pressure immobilisation bandages applied).<ref name="MJA2005-Isbister"/> Death may occur within a period ranging from 15 minutes<ref name="ClinExp2002-Nicholson"/> (this occurred when a small child was bitten) to three days.
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