Editing B cell (section)

==B cell-related pathology==
Autoimmune disease can result from abnormal B cell recognition of self-antigens followed by the production of autoantibodies.<ref name=":16">{{cite journal | vauthors = Yanaba K, Bouaziz JD, Matsushita T, Magro CM, St Clair EW, Tedder TF | title = B-lymphocyte contributions to human autoimmune disease | journal = Immunological Reviews | volume = 223 | issue = 1 | pages = 284–299 | date = June 2008 | pmid = 18613843 | doi = 10.1111/j.1600-065X.2008.00646.x | s2cid = 11593298 }}</ref> Autoimmune diseases where disease activity is correlated with B cell activity include [[scleroderma]], [[multiple sclerosis]], [[systemic lupus erythematosus]], [[Diabetes mellitus type 1|type 1 diabetes]], [[Irritable bowel syndrome|post-infectious IBS]], and [[rheumatoid arthritis]].<ref name=":16" />

[[Malignant transformation]] of B cells and their precursors can cause a host of [[cancer]]s, including [[B-cell chronic lymphocytic leukemia|chronic lymphocytic leukemia (CLL)]], [[Acute lymphoblastic leukemia|acute lymphoblastic leukemia (ALL)]], [[hairy cell leukemia]], [[follicular lymphoma]], [[Non-Hodgkin lymphoma|non-Hodgkin's lymphoma]], [[Hodgkin's lymphoma]], and [[Plasma cell dyscrasia|plasma cell malignancies]] such  as [[multiple myeloma]], [[Waldenström's macroglobulinemia]], and certain forms of [[amyloidosis]].<ref>{{cite journal | vauthors = Shaffer AL, Young RM, Staudt LM | title = Pathogenesis of human B cell lymphomas | journal = Annual Review of Immunology | volume = 30 | issue = 1 | pages = 565–610 | date = 2012-01-01 | pmid = 22224767 | pmc = 7478144 | doi = 10.1146/annurev-immunol-020711-075027 }}</ref><ref name="pmid27866585">{{cite journal | vauthors = Castillo JJ | title = Plasma Cell Disorders | journal = Primary Care | volume = 43 | issue = 4 | pages = 677–691 | date = December 2016 | pmid = 27866585 | doi = 10.1016/j.pop.2016.07.002 }}</ref>

Abnormal B cells may be relatively large and some diseases include this in their names, such as [[diffuse large B-cell lymphoma]]s (DLBCLs) and [[intravascular large B-cell lymphoma]].

Patients with B cell alymphocytosis are predisposed to infections.<ref>Grammatikos Alexandros, Donati Matthew, Johnston Sarah L., Gompels Mark M. Peripheral B Cell Deficiency and Predisposition to Viral Infections: The Paradigm of Immune Deficiencies. Frontiers in Immunology (12)2021 https://www.frontiersin.org/articles/10.3389/fimmu.2021.731643 DOI=10.3389/fimmu.2021.731643</ref>