Editing Benzophenone (section)

==Safety==
It is considered "essentially nontoxic".<ref name=Ull/> Benzophenone is however banned as a food additive by the US [[Food and Drug Administration]], despite the FDA's continuing stance that this chemical does not pose a risk to public health under the conditions of its intended use.<ref>{{Cite news|url=https://www.npr.org/sections/thesalt/2018/10/06/655135633/fda-bans-use-of-7-synthetic-food-additives-after-environmental-groups-sue|title=FDA Bans Use of 7 Synthetic Food Additives After Environmental Groups Sue|work=NPR.org|access-date=2018-10-09|language=en}}</ref><ref>{{Federal Register|83|50490}}</ref> 

The European Union permits it as a flavouring substance,<ref>{{Cite report|url=https://www.canada.ca/en/environment-climate-change/services/evaluating-existing-substances/risk-management-approach-benzophenone.html#toc25|title=Risk management approach for benzophenone|date=Jan 2001|publisher=Health Canada|language=en}}</ref> having established a Total Dietary Intake of 0.3mg/kg of body weight per day.<ref>{{Cite journal|title=Safety of benzophenone to be used as flavouring|date=14 November 2017|journal=EFSA Journal|volume=15|issue=11|doi=10.2903/j.efsa.2017.5013|language=en|hdl=2164/9927|hdl-access=free |last1=Silano |first1=Vittorio |last2=Bolognesi |first2=Claudia |last3=Castle |first3=Laurence |last4=Chipman |first4=Kevin |last5=Cravedi |first5=Jean-Pierre |last6=Engel |first6=Karl-Heinz |last7=Fowler |first7=Paul |last8=Franz |first8=Roland |last9=Grob |first9=Konrad |last10=Gürtler |first10=Rainer |last11=Husøy |first11=Trine |last12=Kärenlampi |first12=Sirpa |last13=Milana |first13=Maria Rosaria |last14=Pfaff |first14=Karla |last15=Riviere |first15=Gilles |last16=Srinivasan |first16=Jannavi |last17=Tavares Poças |first17=Maria de Fátima |last18=Tlustos |first18=Christina |last19=Wölfle |first19=Detlef |last20=Zorn |first20=Holger |last21=Benigni |first21=Romualdo |last22=Binderup |first22=Mona-Lise |last23=Brimer |first23=Leon |last24=Marcon |first24=Francesca |last25=Marzin |first25=Daniel |last26=Mosesso |first26=Pasquale |last27=Mulder |first27=Gerard |last28=Oskarsson |first28=Agneta |last29=Svendsen |first29=Camilla |last30=Anastassiadou |first30=Maria |pages=e05013 |pmid=32625332 |pmc=7010149 |display-authors=1 }}</ref>

Benzophenone derivatives are known to be pharmacologically active. From a molecular chemistry point of view interaction of benzophenone with B-DNA has been demonstrated experimentally.<ref>{{cite journal |author1=Consuelo Cuquerella, M. |author2=Lhiaubet-Vallet, V. |author3=Cadet, J. |author4=Miranda, M. A. | journal = Acc. Chem. Res. | volume = 45 |issue=9 | pages = 1558–1570 | year = 2012 | doi=10.1021/ar300054e |pmid=22698517 | title = Benzophenone Photosensitized DNA Damage}}</ref> The interaction with DNA and the successive photo-induced energy transfer is at the base of the benzophenone activity as a DNA photosensitizer and may explain part of its therapeutic potentialities.

In 2014, benzophenones were named Contact [[Allergen of the Year]] by the American Contact Dermatitis Society.<ref>{{cite web |author=Doug Brunk |url=http://www.skinandallergynews.com/single-view/benzophenones-named-2014-contact-allergen-of-the-year/cb086f7e351cccbcfd9dbf5fa806762b.html |title=Benzophenones named 2014 Contact Allergen of the Year : Dermatology News |website=Skinandallergynews.com |date=2014-03-14 |access-date=2016-06-16 |archive-url=https://web.archive.org/web/20160322084615/http://www.edermatologynews.com/single-view/benzophenones-named-2014-contact-allergen-of-the-year/cb086f7e351cccbcfd9dbf5fa806762b.html |archive-date=2016-03-22}}</ref>

Benzophenone is an [[endocrine disruptor]] capable of binding to the [[pregnane X receptor]].<ref>{{cite journal | doi = 10.1016/j.taap.2003.08.001| pmid = 14613717| title = Endocrine disruptors induce cytochrome P450 by affecting transcriptional regulation via pregnane X receptor| journal = Toxicology and Applied Pharmacology| volume = 193| issue = 1| pages = 66–72| year = 2003| last1 = Mikamo| first1 = Eriko| last2 = Harada| first2 = Shingo| last3 = Nishikawa| first3 = Jun-Ichi| last4 = Nishihara| first4 = Tsutomu| bibcode = 2003ToxAP.193...66M}}</ref>
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