Editing C-reactive protein (section)

===Acute inflammation===
When there is a stimulus, the CRP level can increase 10,000-fold from less than 50&nbsp;μg/L to more than 500&nbsp;mg/L. Its concentration can increase to 5&nbsp;mg/L by 6 hours and peak at 48 hours. The plasma half-life of CRP is 19 hours, and is constant in all medical conditions.<ref>{{cite journal | vauthors = Vigushin DM, Pepys MB, Hawkins PN | title = Metabolic and scintigraphic studies of radioiodinated human C-reactive protein in health and disease | journal = The Journal of Clinical Investigation | volume = 91 | issue = 4 | pages = 1351–1357 | date = April 1993 | pmid = 8473487 | pmc = 288106 | doi = 10.1172/JCI116336 }}</ref> Therefore, the only factor that affects the blood CRP concentration is its production rate, which increases with inflammation, infection, trauma, necrosis, malignancy, and [[allergic reaction]]s.{{citation needed|date=August 2023}} Other inflammatory mediators that can increase CRP are [[TGF beta 1]], and [[tumor necrosis factor alpha]]. In acute inflammation, CRP can increase as much as 50 to 100&nbsp;mg/L within 4 to 6 hours in mild to moderate inflammation or an insult such as [[skin infection]], [[cystitis]], or [[bronchitis]]{{clarify|date=August 2022}}. It can double every 8 hours and reaches its peak at 36 to 50 hours following injury or inflammation. CRP between 100 and 500&nbsp;mg/L is considered highly predictive of inflammation due to bacterial infection.  Once inflammation subsides, CRP level falls quickly because of its relatively short half-life.<ref name="Bray 2016"/>