Editing Calmodulin (section)

==== Role in metabolism ====
Calmodulin plays an important role in the activation of [[phosphorylase kinase]], which ultimately leads to [[glucose]] being cleaved from [[glycogen]] by [[glycogen phosphorylase]].<ref name="Nishizawa-1988">{{cite journal | vauthors = Nishizawa Y, Okui Y, Inaba M, Okuno S, Yukioka K, Miki T, Watanabe Y, Morii H | display-authors = 6 | title = Calcium/calmodulin-mediated action of calcitonin on lipid metabolism in rats | journal = The Journal of Clinical Investigation | volume = 82 | issue = 4 | pages = 1165–72 | date = October 1988 | pmid = 2844851 | pmc = 442666 | doi = 10.1172/jci113713 }}</ref>

Calmodulin also plays an important role in [[lipid metabolism]] by affecting [[Calcitonin gene-related peptide|calcitonin]]. Calcitonin is a polypeptide hormone that lowers blood Ca<sup>2+</sup> levels and activates [[G protein|Gs protein]] cascades that leads to the generation of cAMP. The actions of calcitonin can be blocked by inhibiting the actions of calmodulin, suggesting that calmodulin plays a crucial role in the activation of calcitonin.<ref name="Nishizawa-1988" />