Editing Cluster headache (section)

===Genetics===
Cluster headache may run in some families in an [[autosomal dominant]] inheritance pattern.<ref name="updateongenetics">{{cite journal |vauthors=Waung MW, Taylor A, Qualmann KJ, Burish MJ| title = Family History of Cluster HeadacheA Systematic Review | journal = JAMA Neurology| date = 2020 | volume = 77 | issue = 7 | pages = 887–896 | doi = 10.1001/jamaneurol.2020.0682 | pmid = 32310255 | pmc = 7644512 }}</ref><ref name="Pinessi2005">{{cite journal |last1=Pinessi |first1=L. |last2=Rainero |first2=I. |last3=Rivoiro |first3=C. |last4=Rubino |first4=E. |last5=Gallone |first5=S. |year=2005 |title=Genetics of cluster headache: An update |journal=[[The Journal of Headache and Pain]] |volume=6 |issue=4 |pages=234–6 |doi=10.1007/s10194-005-0194-x |pmc=3452030 |pmid=16362673}}</ref> People with a [[Consanguinity|first degree relative]] with the condition are about 14–48 times more likely to develop it themselves,<ref name=Nesbitt2012 /> and around 8 to 10% of persons with cluster headaches have a family history.<ref name="updateongenetics" /><ref name=":0">{{Cite journal|last1=O'Connor|first1=Emer|last2=Simpson|first2=Benjamin S.|last3=Houlden|first3=Henry|last4=Vandrovcova|first4=Jana|last5=Matharu|first5=Manjit|date=2020-04-25|title=Prevalence of familial cluster headache: a systematic review and meta-analysis|journal=[[The Journal of Headache and Pain]]|volume=21|issue=1|pages=37|doi=10.1186/s10194-020-01101-w|issn=1129-2377|pmc=7183702|pmid=32334514 |doi-access=free }}</ref> Several studies have found a higher number of relatives affected among females.<ref name=":0" /> Others have suggested these observations may be due to lower numbers of females in these studies.<ref name=":0" /> Possible genetic factors warrant further research, current evidence for genetic inheritance is limited.<ref name=Pinessi2005 />

Genes that are thought to play a role in the disease are the hypocretin/orexin receptor type 2 (HCRTR2), alcohol dehydrogenase 4(ADH4), G protein beta 3 (GNB3), pituitary adenylate cyclase-activating polypeptide type I receptor (ADCYAP1R1), and membrane metalloendopeptidase (MME) genes.<ref name="updateongenetics" />