Editing Common cold (section)

==Pathophysiology==
[[File:Illu conducting passages.svg|thumb|upright|The common cold is a disease of the [[upper respiratory tract]].]]
The symptoms of the common cold are believed to be primarily related to the [[immune]] response to the virus.<ref name=E112/> The mechanism of this immune response is virus-specific. For example, the rhinovirus is typically acquired by direct contact; it binds to humans via [[ICAM-1|ICAM-1 receptors]] and the [[Cadherin related family member 3|CDHR3 receptor]] through unknown mechanisms to trigger the release of [[inflammatory mediators]].<ref name=E112/> These inflammatory mediators then produce the symptoms.<ref name=E112/> It does not generally cause damage to the nasal [[epithelium]].<ref name=Eccles2005/> The respiratory syncytial virus ([[Human respiratory syncytial virus|RSV]]), on the other hand, is contracted by direct contact and airborne droplets. It then replicates in the nose and throat before spreading to the [[lower respiratory tract]].<ref name=E116>Eccles p. 116</ref> RSV does cause epithelium damage.<ref name=E116/> Human [[parainfluenza]] virus typically results in inflammation of the nose, throat, and [[bronchus|bronchi]].<ref name=E122>Eccles p. 122</ref> In young children, when it affects the [[Vertebrate trachea|trachea]], it may produce the symptoms of [[croup]], due to the small size of their airways.<ref name=E122/>