Editing Corticotropic cell (section)

=== Cushing's Disease ===
Corticotropic cells can have detrimental effects on the body if they express too much or too little ACTH. One such example is [[Cushing's disease]], which can result from overproduction of ACTH in the corticotropes due to pituitary tumors known as corticotroph [[Pituitary adenoma|adenomas]]; this is the cause for roughly two-thirds of those diagnosed with Cushing's disease.<ref>{{Citation|last1=Tanase|first1=Cristiana Pistol |last2=Ogrezeanu|first2=Irina|last3=Badiu|first3=Corin | name-list-style = vanc |title=Pituitary Tumor Classification|date=2012  |work=Molecular Pathology of Pituitary Adenomas|pages=1–18|publisher=Elsevier | doi=10.1016/b978-0-12-415830-6.00001-9|isbn=9780124158306 }}</ref> It is also possible that this disease can result from production of ACTH in a non-pituitary tumor, known as ectopic production, or the adrenal glands can overproduce cortisol due to an adrenal tumor.<ref>{{cite journal | vauthors = Bertagna X, Guignat L, Groussin L, Bertherat J | title = Cushing's disease | journal = Best Practice & Research. Clinical Endocrinology & Metabolism | volume = 23 | issue = 5 | pages = 607–23 | date = October 2009 | pmid = 19945026 | doi = 10.1016/j.beem.2009.06.001 }}</ref> This overproduction of ACTH causes an increase in cortisol levels due to increased glucocorticoid synthesis in the adrenal cortex resulting in several associated symptoms.

Symptoms of Cushing's disease include:

* Fatty deposits in the neck or back
* [[Stretch marks]] (striae)<ref name="Barthel_2016">{{cite book |last1=Barthel |first1=Andreas |last2=Willenberg |first2=Holger S. |last3=Gruber |first3=Matthias |last4=Bornstein |first4=Stefan R. | name-list-style = vanc |title=Adrenal Insufficiency |date=2016 |work=Endocrinology: Adult and Pediatric|pages=1763–1774.e4 |publisher=Elsevier | doi=10.1016/b978-0-323-18907-1.00102-5|isbn=9780323189071 }}</ref>
* Fatigue<ref name="Barthel_2016" />
* [[Osteoporosis]]<ref name="Barthel_2016" />
* Weakened immune system<ref name="Barthel_2016" />
* [[Hypertension]]<ref name="Barthel_2016" />