Editing Depression (mood) (section)

=== Non-psychiatric illnesses ===
{{main|Depression (differential diagnoses)}}
Depressed mood can be the result of a number of infectious diseases, [[Nutritional deficiency|nutritional deficiencies]], neurological conditions, and physiological problems, including [[hypoandrogenism]] (in men), [[Addison's disease]], [[Cushing's syndrome]], [[pernicious anemia]], [[hypothyroidism]], [[hyperparathyroidism]], [[Lyme disease]], [[multiple sclerosis]], [[Parkinson's disease]], [[celiac disease]],<ref>{{Cite journal |last1=Zingone |first1=Fabiana |last2=Swift |first2=Gillian L |last3=Card |first3=Timothy R |last4=Sanders |first4=David S |last5=Ludvigsson |first5=Jonas F |last6=Bai |first6=Julio C |date=April 2015 |title=Psychological morbidity of celiac disease: A review of the literature |journal=United European Gastroenterology Journal |language=en |volume=3 |issue=2 |pages=136–145 |doi=10.1177/2050640614560786 |issn=2050-6406 |pmc=4406898 |pmid=25922673}}</ref> chronic pain, stroke, diabetes, cancer, and HIV.<ref>Murray ED, Buttner N, Price BH. (2012) "Depression and Psychosis in Neurological Practice". In: Neurology in Clinical Practice, 6th Edition. Bradley WG, Daroff RB, Fenichel GM, Jankovic J (eds.) Butterworth Heinemann {{ISBN|978-1437704341}}{{page needed|date=November 2023}}</ref><ref>{{cite journal |vauthors=Rustad JK, Musselman DL, Nemeroff CB |date=October 2011 |title=The relationship of depression and diabetes: pathophysiological and treatment implications |journal=Psychoneuroendocrinology |volume=36 |issue=9 |pages=1276–86 |doi=10.1016/j.psyneuen.2011.03.005 |pmid=21474250 |s2cid=32439196}}</ref><ref>{{cite journal |vauthors=Li M, Fitzgerald P, Rodin G |date=April 2012 |title=Evidence-based treatment of depression in patients with cancer |journal=Journal of Clinical Oncology |volume=30 |issue=11 |pages=1187–96 |doi=10.1200/JCO.2011.39.7372 |pmid=22412144}}</ref>

Studies have found that anywhere from 30 to 85 percent of patients suffering from chronic pain are also clinically depressed.<ref>{{cite journal |last1=Sheng |first1=Jiyao |last2=Liu |first2=Shui |last3=Wang |first3=Yicun |last4=Cui |first4=Ranji |last5=Zhang |first5=Xuewen |title=The Link between Depression and Chronic Pain: Neural Mechanisms in the Brain |journal=Neural Plasticity |date=2017 |volume=2017 |pages=1–10 |doi=10.1155/2017/9724371 |pmc=5494581 |pmid=28706741 |doi-access=free }}</ref><ref>{{cite journal |last1=Surah |first1=A |last2=Baranidharan |first2=G |last3=Morley |first3=S |title=Chronic pain and depression |journal=Continuing Education in Anaesthesia Critical Care & Pain |date=April 2014 |volume=14 |issue=2 |pages=85–89 |doi=10.1093/bjaceaccp/mkt046 |doi-access=free }}</ref><ref>{{cite journal |last1=Holmes |first1=Alex |last2=Christelis |first2=Nicholas |last3=Arnold |first3=Carolyn |title=Depression and chronic pain |journal=Medical Journal of Australia |date=October 2013 |volume=199 |issue=S6 |pages=S17-20 |doi=10.5694/mja12.10589 |pmid=25370278 |s2cid=27576624 }}</ref> A 2014 study by Hooley et al. concluded that chronic pain increased the chance of death by suicide by two to three times.<ref>{{Cite web |last=U.S. Department of Veterans Affairs |date=2022 |title=Managing Chronic Pain May Protect Against Suicide Risk |url=https://www.mentalhealth.va.gov/suicide_prevention/docs/FSTP-Chronic-Pain.pdf}}</ref> In 2017, the British Medical Association found that 49% of UK chronic pain patients also had depression.<ref>{{Cite web |date=2017 |title=Chronic pain: supporting safer prescribing of analgesics |url=https://www.bma.org.uk/media/2100/analgesics-chronic-pain.pdf |publisher=British Medical Association}}</ref>

As many as 1/3 of stroke survivors will later develop [[post-stroke depression]]. Because strokes may cause damage to the parts of the brain involved in processing emotions, reward, and cognition, stroke may be considered a direct cause of depression.<ref>{{Cite journal |last1=Medeiros |first1=Gustavo C. |last2=Roy |first2=Durga |last3=Kontos |first3=Nicholas |last4=Beach |first4=Scott R. |date=2020-09-01 |title=Post-stroke depression: A 2020 updated review |url=https://linkinghub.elsevier.com/retrieve/pii/S0163834320300955 |journal=General Hospital Psychiatry |volume=66 |pages=70–80 |doi=10.1016/j.genhosppsych.2020.06.011 |pmid=32717644 |issn=0163-8343|url-access=subscription }}</ref>