Editing Digitoxin (section)

===Pharmacokinetics===
The drug is almost completely absorbed from the gut. When in the bloodstream, 90 to 97% are bound to [[plasma protein]]s. Digitoxin undergoes [[enterohepatic circulation]]. It is [[metabolized]] in part by CYP3A4; metabolites include [[digitoxigenin]], [[digoxin]] (>2%), and [[conjugation (biochemistry)|conjugate esters]]. In healthy people, 60% are eliminated via the kidneys and 40% via the faeces. In people with impaired kidney function, elimination via the faeces is increased. The [[biological half-life]] is 7 to 8 days except when kidney ''and'' liver functions are impaired, in which case it is usually longer.<ref name="AC" /><ref>{{cite web|url=https://www.mediq.ch/|title=mediQ: Digitoxin|access-date=2021-09-14}}</ref>