Editing Entactogen (section)

==Interactions==
{{See also|MDMA#Interactions|Trip killer#Antidotes of other hallucinogens|MDMA/citalopram}}

Entactogens like MDMA pose high risks of severe and potentially fatal [[serotonin syndrome]] and [[hypertensive crisis]] in people on [[monoamine oxidase inhibitor]]s (MAOIs) due to synergistic elevations of [[monoamine]]s like [[serotonin]] and [[norepinephrine]].<ref name="MalcolmThomas2022">{{cite journal | vauthors = Malcolm B, Thomas K | title = Serotonin toxicity of serotonergic psychedelics | journal = Psychopharmacology (Berl) | volume = 239 | issue = 6 | pages = 1881–1891 | date = June 2022 | pmid = 34251464 | doi = 10.1007/s00213-021-05876-x | url = }}</ref><ref name="EdinoffSwinfordOdisho2022">{{cite journal | vauthors = Edinoff AN, Swinford CR, Odisho AS, Burroughs CR, Stark CW, Raslan WA, Cornett EM, Kaye AM, Kaye AD | title = Clinically Relevant Drug Interactions with Monoamine Oxidase Inhibitors | journal = Health Psychol Res | volume = 10 | issue = 4 | pages = 39576 | date = 2022 | pmid = 36425231 | pmc = 9680847 | doi = 10.52965/001c.39576 | doi-broken-date = 14 May 2025 | url = }}</ref> MDMA also has the potential to interact with various other drugs.<ref name="PapaseitPérez-MañáTorrens2020">{{cite journal | vauthors = Papaseit E, Pérez-Mañá C, Torrens M, Farré A, Poyatos L, Hladun O, Sanvisens A, Muga R, Farré M | title = MDMA interactions with pharmaceuticals and drugs of abuse | journal = Expert Opin Drug Metab Toxicol | volume = 16 | issue = 5 | pages = 357–369 | date = May 2020 | pmid = 32228243 | doi = 10.1080/17425255.2020.1749262 | url = }}</ref><ref name="SarparastThomasMalcolm2022">{{cite journal | vauthors = Sarparast A, Thomas K, Malcolm B, Stauffer CS | title = Drug-drug interactions between psychiatric medications and MDMA or psilocybin: a systematic review | journal = Psychopharmacology (Berl) | volume = 239 | issue = 6 | pages = 1945–1976 | date = June 2022 | pmid = 35253070 | pmc = 9177763 | doi = 10.1007/s00213-022-06083-y | url = }}</ref><ref name="MohamedBenHamidaCassel2011">{{cite journal | vauthors = Mohamed WM, Ben Hamida S, Cassel JC, de Vasconcelos AP, Jones BC | title = MDMA: interactions with other psychoactive drugs | journal = Pharmacol Biochem Behav | volume = 99 | issue = 4 | pages = 759–774 | date = October 2011 | pmid = 21756931 | doi = 10.1016/j.pbb.2011.06.032 | url = }}</ref>