Editing Entorhinal cortex (section)

==Clinical significance==
===Alzheimer's disease===
The entorhinal cortex is the first area of the brain to be affected in [[Alzheimer's disease]]; in year 2013, a [[functional magnetic resonance imaging]] study has localised the area to the lateral entorhinal cortex.<ref>{{cite journal|vauthors=Khan UA, Liu L, Provenzano FA, Berman DE, Profaci CP, Sloan R, Mayeux R, Duff KE, Small SA |year=2013|title=Molecular drivers and cortical spread of lateral entorhinal cortex dysfunction in preclinical Alzheimer's disease|journal=[[Nature Neuroscience]]|doi=10.1038/nn.3606|volume=17|issue=2|pages=304–311|pmc=4044925|pmid=24362760}}</ref> Lopez ''et al.''<ref>{{cite journal|last1=Lopez|first1=M. E.|last2=Bruna|first2=R.|last3=Aurtenetxe|first3=S.|last4=Pineda-Pardo|first4=J. A.|last5=Marcos|first5=A.|last6=Arrazola|first6=J.|last7=Reinoso|first7=A. I.|last8=Montejo|first8=P.|last9=Bajo|first9=R.|last10=Maestu|first10=F.|title=Alpha-Band Hypersynchronization in Progressive Mild Cognitive Impairment: A Magnetoencephalography Study|journal=Journal of Neuroscience|date=2014|volume=34|issue=44|pages=14551–14559|doi=10.1523/JNEUROSCI.0964-14.2014|pmid=25355209|pmc=6608420}}</ref> have shown, in a multimodal study, that there are differences in the volume of the left entorhinal cortex between progressing (to Alzheimer's disease) and stable mild cognitive impairment patients. These authors also found that the volume of the left entorhinal cortex inversely correlates with the level of alpha band phase synchronization between the right anterior cingulate and temporo-occipital regions.

In 2012, neuroscientists at [[UCLA]] conducted an experiment using a virtual taxi video game connected to seven epilepsy patients with electrodes already implanted in their brains, allowing the researchers to monitor neuronal activity whenever memories were being formed. As the researchers stimulated the nerve fibers of each of the patients' entorhinal cortex as they were learning, they were then able to better navigate themselves through various routes and recognize landmarks more quickly. This signified an improvement in the patients' spatial memory.<ref>{{cite journal|last1=Suthana|first1=N.|last2=Haneef|first2=Z.|last3=Stern|first3=J.|last4=Mukamel|first4=R.|last5=Behnke|first5=E.|last6=Knowlton|first6=B.|last7=Fried|first7=I.|year=2012|title=Memory Enhancement and Deep-Brain Stimulation of the Entorhinal Area|journal=[[New England Journal of Medicine]]|doi=10.1056/NEJMoa1107212|volume=366|issue=6|pages=502–510|pmc=3447081|pmid=22316444}}</ref>