Editing Integrin (section)

== Integrins and nerve repair ==
Integrins have an important function in [[neuroregeneration]] after injury of the [[peripheral nervous system]] (PNS).<ref name="Nieuwenhuis2018a">{{cite journal | vauthors = Nieuwenhuis B, Haenzi B, Andrews MR, Verhaagen J, Fawcett JW | title = Integrins promote axonal regeneration after injury of the nervous system | journal = Biological Reviews of the Cambridge Philosophical Society | volume =  93| issue =  3| pages = 1339–1362 | date = February 2018 | pmid = 29446228 | pmc = 6055631 | doi = 10.1111/brv.12398 }}</ref> Integrins are present at the [[growth cone]] of damaged PNS neurons and attach to ligands in the ECM to promote axon regeneration. It is unclear whether integrins can promote axon regeneration in the adult [[central nervous system]] (CNS). There are two obstacles that prevent integrin-mediated regeneration in the CNS: 1) integrins are not localised in the axon of most adult CNS neurons and 2) integrins become inactivated by molecules in the scar tissue after injury.<ref name=Nieuwenhuis2018a/>