Editing Irish Setter (section)

==Health==
A 2024 UK study found a life expectancy of 12.9 years for the breed compared to an average of 12.7 for purebreeds and 12 for [[Mongrel|crossbreeds]].<ref>{{cite journal | last1=McMillan | first1=Kirsten M. | last2=Bielby | first2=Jon | last3=Williams | first3=Carys L. | last4=Upjohn | first4=Melissa M. | last5=Casey | first5=Rachel A. | last6=Christley | first6=Robert M. | title=Longevity of companion dog breeds: those at risk from early death | journal=Scientific Reports | publisher=Springer Science and Business Media LLC | volume=14 | issue=1 | date=2024-02-01 | issn=2045-2322 | doi=10.1038/s41598-023-50458-w | page=531| pmid=38302530 | pmc=10834484 | bibcode=2024NatSR..14..531M }}</ref>

Gluten intolerance in Irish Setters is a naturally occurring genetic disorder that is the result of a single autosomal recessive locus.<ref>{{Cite journal|last1=Garden|first1=Oliver A|last2=Pidduck|display-authors=1|date=2000|title=Inheritance of gluten-sensitive enteropathy in Irish Setters|journal=American Journal of Veterinary Research|volume=61|issue=4|pages=462–468|doi=10.2460/ajvr.2000.61.462|pmid=10772115|url=http://researchonline.rvc.ac.uk/id/eprint/6890/ |doi-access=free}}</ref>&nbsp;At around 6 months of age, Irish Setters with this condition will develop an increased immune cell presence and a decrease in absorption within the small intestine when fed a gluten containing diet. These effects lead to further damage of the small intestine as well as malnutrition and diarrhea. Irish Setters that are fed a gluten free diet have been shown to be exempt from any effects associated with gluten intolerance.<ref>{{Cite journal|last1=Hall|first1=EJ|last2=Batt|first2=R.M|date=1990|title=Development of wheat-sensitive enteropathy in Irish Setters: morphologic changes|journal=American Journal of Veterinary Research|volume=51|issue=7|pages=978–982|doi=10.2460/ajvr.1990.51.07.978 |pmid=2389896}}</ref><ref>{{cite journal |last=Hall |first=E J |author2=R M Batt |date=February 1992 |title=Dietary modulation of gluten sensitivity in a naturally occurring enteropathy of Irish setter dogs |journal=Gut |volume=33 |issue=2 |pages=198–205 |pmc=1373930 |quote=These findings document a gluten sensitive enteropathy in Irish setters and indicate that exclusion of dietary cereal from birth may modify subsequent expression of the disease. |doi=10.1136/gut.33.2.198 |pmid=1347279}}</ref>

The breed is predisposed to atopic dermatitis.<ref>{{cite book | last1=Rhodes | first1=Karen Helton | last2=Werner | first2=Alexander H. | title=Blackwell's Five-Minute Veterinary Consult Clinical Companion | publisher=Wiley-Blackwell | publication-place=Ames, Iowa | date=2011-01-25 | isbn=978-0-8138-1596-1 | page=94}}</ref>