Editing Kinetic isotope effect (section)

=== Transient kinetic isotope effect ===

{{Main|Transient kinetic isotope fractionation}}

Isotopic effect expressed with the equations given above only refer to reactions that can be described with [[first-order kinetics]]. In all instances in which this is not possible, [[Transient kinetic isotope fractionation|transient KIEs]] should be taken into account using the GEBIK and GEBIF equations.<ref name="Maggi">{{cite journal
 | vauthors = Maggi F, Riley WJ
 |year=2010
 |title=Mathematical treatment of isotopologue and isotopomer speciation and fractionation in biochemical kinetics
 |journal=[[Geochimica et Cosmochimica Acta]]
 |volume=74 |issue=6 |page=1823
 |bibcode=2010GeCoA..74.1823M
 |doi=10.1016/j.gca.2009.12.021
|s2cid=55422661
 |url=http://www.escholarship.org/uc/item/0x8927jx
 }}</ref>