Editing Linezolid (section)

===Specific populations===
In adults and children over the age of 12, linezolid is usually given every 12 hours, whether orally or intravenously.<ref name=Moellering/><ref name="American Family Physician"/> In younger children and infants, it is given every eight hours.<ref name=Buck>{{cite journal | vauthors = Buck ML |title=Linezolid use for resistant Gram-positive infections in children |journal=Pediatric Pharmacotherapy |volume=9 |issue=6 |date=June 2003 |url=http://www.healthsystem.virginia.edu/alive/pediatrics/PharmNews/200306.pdf |access-date=8 June 2009 |url-status=dead |archive-url=https://web.archive.org/web/20110605115607/http://www.healthsystem.virginia.edu/alive/pediatrics/PharmNews/200306.pdf |archive-date=5 June 2011 }}</ref> No dosage adjustments are required in the elderly, in people with mild-to-moderate liver failure, or in those with impaired kidney function.<ref name=Lexi-Comp/> In people requiring [[hemodialysis]], care should be taken to give linezolid after a session, because dialysis removes 30–40% of a dose from the body; no dosage adjustments are needed in people undergoing [[hemofiltration|continuous hemofiltration]],<ref name=Lexi-Comp/> although more frequent administration may be warranted in some cases.<ref name=Herrmann/> According to one study, linezolid may need to be given more frequently than normal in people with [[burn]]s affecting more than 20% of [[total body surface area|body area]], due to increased nonrenal clearance of the drug.<ref>{{cite journal  |vauthors=Lovering AM, Le Floch R, Hovsepian L, etal |title=Pharmacokinetic evaluation of linezolid in patients with major thermal injuries |journal=Journal of Antimicrobial Chemotherapy |volume=63 |issue=3 |pages=553–9 |date=March 2009 |pmid=19153078 |doi=10.1093/jac/dkn541 |issn=0305-7453|doi-access=free }}</ref>

Linezolid is in U.S. [[pregnancy category]] C, meaning there have been no adequate studies of its safety when used by pregnant women, and although animal studies have shown mild toxicity to the fetus, the benefits of using the drug may outweigh its risks.<ref name="Zyvox FDA label" /> It also passes into [[breast milk]], although the clinical significance of this (if any) is unknown.<ref name=InfectiousDiseases/>