Editing Luteinizing hormone (section)

=== Effects in the brain ===
Luteinizing hormone receptors are located in areas of the brain associated with [[cognitive function]].<ref name="Blair_2015" /> The role of LH role in the [[central nervous system]] (CNS) may be of relevance to understanding and treating post-menopausal cognitive decline.<ref>{{Cite journal | vauthors = Than S, Moran C, Beare R, Vincent A, Lane E, Collyer TA, Callisaya ML, Srikanth V |date=2023 |title=Cognitive trajectories during the menopausal transition |journal=Frontiers in Dementia |volume=2 |doi=10.3389/frdem.2023.1098693 |issn=2813-3919 | doi-access = free |pmid=39081973 |pmc=11285668 }}</ref>

Some research has observed an inverse relationship between circulating LH and CNS LH levels.<ref>{{cite journal | vauthors = Bhatta S, Blair JA, Casadesus G | title = Luteinizing Hormone Involvement in Aging Female Cognition: Not All Is Estrogen Loss | journal = Frontiers in Endocrinology | volume = 9 | pages = 544 | date = 24 September 2018 | pmid = 30319538 | pmc = 6165885 | doi = 10.3389/fendo.2018.00544 | doi-access = free }}</ref> After ovariectomy (a procedure used to mimic menopause) in female mice, circulating LH levels surge while CNS levels of LH fall.<ref name="Blair_2015">{{cite journal | vauthors = Blair JA, Bhatta S, McGee H, Casadesus G | title = Luteinizing hormone: Evidence for direct action in the CNS | journal = Hormones and Behavior | volume = 76 | pages = 57–62 | date = November 2015 | pmid = 26172857 | pmc = 4741372 | doi = 10.1016/j.yhbeh.2015.06.020 }}</ref> Treatments that lower circulating LH restore LH levels in the CNS.<ref name="Blair_2015" />