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Lycopene
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===Sources=== {| class="wikitable" table style="border:1px #000000;" cellspacing="0" align="left" style="margin-right: 1em" |- |+Dietary sources of lycopene<ref name=lpi/> |- ! width="100" | Source ! width="150" | mg wet weight |- | [[Gac]] aril | 2~6 per gram<ref>{{cite journal|last1=Ishida|first1=BK|last2=Turner|first2=C|last3=Chapman|first3=MH|last4=McKeon|first4=TA|title=Fatty acid and carotenoid composition of gac (Momordica cochinchinensis Spreng) fruit|journal=Journal of Agricultural and Food Chemistry|date=28 January 2004|volume=52|issue=2|pages=274–9|doi=10.1021/jf030616i|pmid=14733508|bibcode=2004JAFC...52..274I }}</ref><ref>{{cite web|title=Gac (Momordica cochinchinensis) Analysis report|url=https://www.volkerkleinhenz.com/presentations/Gac-Analysis-Report.pdf|access-date=2018-04-13|archive-date=2018-04-13|archive-url=https://web.archive.org/web/20180413125442/https://www.volkerkleinhenz.com/presentations/Gac-Analysis-Report.pdf|url-status=dead}}</ref> |- | Raw [[tomato]] | 4.6 per [[cup (unit)|cup]] |- | Tomato juice | 22 per cup |- | Tomato paste | 75 per cup |- | Tomato [[ketchup]] | 2.5 per [[tablespoon]] |- | [[Watermelon]] | 13 per wedge |- | [[Pink grapefruit]] | 2 per half grapefruit |- |} [[Fruit]]s and [[vegetable]]s that are high in lycopene include [[autumn olive]], [[gac]], tomatoes, [[watermelon]], pink [[grapefruit]], pink [[guava]], [[papaya]], [[seabuckthorn]], [[wolfberry]] ([[goji]], a berry relative of tomato), and [[rosehip]].<ref name=lpi/> [[Ketchup]] is a common dietary source of lycopene.<ref name=lpi/> Although [[gac]] (''Momordica cochinchinensis'' Spreng) has the highest content of lycopene of any known fruit or vegetable (multiple times more than tomatoes),<ref name="tran">{{cite journal|pmc=4779482|year=2015|last1=Tran|first1=X. T.|title=Effects of maturity on physicochemical properties of Gac fruit (Momordica cochinchinensis Spreng.)|journal=Food Science & Nutrition|volume=4|issue=2|pages=305–314|last2=Parks|first2=S. E.|last3=Roach|first3=P. D.|last4=Golding|first4=J. B.|last5=Nguyen|first5=M. H.|doi=10.1002/fsn3.291|pmid=27004120}}</ref><ref name="Ishida2004">{{Cite journal|vauthors=Ishida BK, Turner C, Chapman MH, McKeon TA |title=Fatty acid and carotenoid composition of gac (Momordica cochinchinensis Spreng) fruit |journal=[[Journal of Agricultural and Food Chemistry]] |volume=52 |issue=2 |pages=274–9 |date=January 2004 |pmid=14733508 |doi=10.1021/jf030616i |bibcode=2004JAFC...52..274I }}</ref> tomatoes and tomato-based sauces, juices, and ketchup account for more than 85% of the dietary intake of lycopene for most people.<ref name=lpi/> The lycopene content of tomatoes depends on variety and increases as the fruit ripens.<ref>{{cite journal|pmid=26462607|year=2016|last1=Ilahy|first1=R|title=Fractionate analysis of the phytochemical composition and antioxidant activities in advanced breeding lines of high-lycopene tomatoes|journal=Food Funct|volume=7|issue=1|pages=574–83|last2=Piro|first2=G|last3=Tlili|first3=I|last4=Riahi|first4=A|last5=Sihem|first5=R|last6=Ouerghi|first6=I|last7=Hdider|first7=C|last8=Lenucci|first8=M. S.|doi=10.1039/c5fo00553a}}</ref> Unlike other fruits and vegetables, where nutritional content such as [[vitamin C]] is diminished upon cooking, [[food processing|processing]] of tomatoes increases the concentration of [[Bioavailability|bioavailable]] lycopene.<ref name=lpi/><ref>{{cite journal|url=http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112012000500025&lng=en&nrm=iso&tlng=en|journal=Hospital Nutrition (Madrid)|volume=27|issue=5|year=2012|pages=1542–6|vauthors=Perdomo F, Cabrera Fránquiz F, Cabrera J, Serra-Majem L |title=Influence of cooking procedure on the bioavailability of lycopene in tomatoes|pmid=23478703|doi=10.3305/nh.2012.27.5.5908}}</ref> Lycopene in tomato paste is up to four times more bioavailable than in fresh tomatoes.<ref>{{Cite journal | doi = 10.1002/jsfa.6546| pmid = 24375495| title = Home processing of tomatoes (Solanum lycopersicum): Effects onin vitrobioaccessibility of total lycopene, phenolics, flavonoids, and antioxidant capacity| journal = Journal of the Science of Food and Agriculture| volume = 94| issue = 11| pages = 2225–33| year = 2014| last1 = Kamiloglu | first1 = S. | last2 = Demirci | first2 = M. | last3 = Selen | first3 = S. | last4 = Toydemir | first4 = G. | last5 = Boyacioglu | first5 = D. | last6 = Capanoglu | first6 = E. | bibcode = 2014JSFA...94.2225K}}</ref> Processed tomato products such as pasteurized tomato juice, soup, sauce, and ketchup contain a higher concentration of bioavailable lycopene compared to raw tomatoes.<ref name=lpi/><ref>{{cite book|last1=Yamaguchi|first1=Masayoshi|title=Carotenoids : Properties, Effects and Diseases|date=2010|publisher=Nova Science Publishers|location=New York|isbn=9781612097138|page=125}}</ref> Cooking and crushing tomatoes (as in the [[canning]] process) and serving in oil-rich dishes (such as [[spaghetti]] sauce or [[pizza]]) greatly increases assimilation from the digestive tract into the bloodstream. Lycopene is fat-soluble, so the oil is said to help absorption. Gac has high lycopene content derived mainly from its [[seed coat]]s.<ref>{{Cite journal | pmid = 12506992 | year = 2002 | last1 = Aoki | first1 = H | title = Carotenoid pigments in GAC fruit (Momordica cochinchinensis SPRENG) | journal = Bioscience, Biotechnology, and Biochemistry | volume = 66 | issue = 11 | pages = 2479–82 | last2 = Kieu | first2 = N. T. | last3 = Kuze | first3 = N | last4 = Tomisaka | first4 = K | last5 = Van Chuyen | first5 = N | doi = 10.1271/bbb.66.2479 | s2cid = 2118248 | doi-access = free }}</ref> [[Cara Cara navel orange]]s, and other citrus fruit, such as [[pink grapefruit]]s, also contain lycopene.<ref name=lpi/><ref>{{Cite journal | pmid = 18538806 | year = 2008 | last1 = Alquezar | first1 = B | title = Regulation of carotenoid biosynthesis during fruit maturation in the red-fleshed orange mutant Cara Cara | journal = Phytochemistry | volume = 69 | issue = 10 | pages = 1997–2007 | last2 = Rodrigo | first2 = M. J. | last3 = Zacarías | first3 = L | doi = 10.1016/j.phytochem.2008.04.020 | bibcode = 2008PChem..69.1997A }}</ref> Some foods that do not appear red also contain lycopene, e.g., baked beans.<ref name=lpi/> When lycopene is used as a food additive (E160d), it is usually obtained from tomatoes.<ref name=lpi/><ref>{{cite journal |last1=Li |first1=Lei |last2=Liu |first2=Zhen |last3=Jiang |first3=Hong |last4=Mao |first4=Xiangzhao |title=Biotechnological production of lycopene by microorganisms |journal=Appl. Microbiol. Biotechnol. |date=2020 |volume=104 |issue=24 |pages=10307–10324 |doi=10.1007/s00253-020-10967-4 |pmid=33097966 |s2cid=225058089 |url=https://pubmed.ncbi.nlm.nih.gov/33097966/}}</ref>
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