Editing Mevalonate pathway (section)

==Enzymatic reactions==

{| class="wikitable" 
|-align="center"
| '''Enzyme''' || '''Reaction''' || '''Description''' 
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 | [[Acetoacetyl-CoA thiolase]]  || style="background: light-dark(white,black)"| [[File:Aact1.jpg|class=skin-invert-image|center|400px]]  ||  [[Acetyl-CoA]] ([[citric acid cycle]]) undergoes condensation with another acetyl-CoA molecule to form [[acetoacetyl-CoA]]
 |- 
 |  [[HMG-CoA synthase]]  || style="background: light-dark(white,black)"| [[Image:HMG-CoA synthase.svg|class=skin-invert-image|center|400px]] || Acetoacetyl-CoA condenses with another Acetyl-CoA molecule to form [[3-hydroxy-3-methylglutaryl-CoA|3-'''h'''ydroxy-3-'''m'''ethyl'''g'''lutaryl-CoA]] (HMG-CoA).
 |- 
 | [[HMG-CoA reductase]] || style="background: light-dark(white,black)"| [[Image:HMG-CoA reductase reaction.svg|class=skin-invert-image|center|400px]] || HMG-CoA is reduced to [[mevalonate]] by [[NADPH]]. This is the rate limiting step in cholesterol synthesis, which is why this enzyme is a good target for pharmaceuticals ([[statin]]s). 
 |- 
 | [[Mevalonate kinase|mevalonate-5-kinase]]  || style="background: light-dark(white,black)"| [[Image:Mevalonate kinase reaction.svg|class=skin-invert-image|center|400px]] || Mevalonate is phosphorylated at the 5-OH position to yield [[mevalonate-5-phosphate]] (also called ''phosphomevalonic acid''). 
|- 
 | [[mevalonate-3-kinase]]  || style="background: light-dark(white,black)"| [[Image:M3kwiki3.jpg|class=skin-invert-image|center|400px]] || Mevalonate is phosphorylated at the 3-OH position to yield [[mevalonate-3-phosphate]]. 1 ATP is consumed.
|- 
 | [[mevalonate-3-phosphate-5-kinase]]  || style="background: light-dark(white,black)"| [[File:M35bpK.jpg|class=skin-invert-image|center|400px]] || Mevalonate-3-phosphate is phosphorylated at the 5-OH position to yield [[mevalonate-5-phosphate]] (also called ''phosphomevalonic acid''). 1 ATP is consumed.
 |- 
 | [[phosphomevalonate kinase]] || style="background: light-dark(white,black)"| [[Image:Phosphomevalonate kinase reaction.svg|class=skin-invert-image|center|400px]] || mevalonate-5-phosphate is phosphorylated to yield [[mevalonate-5-pyrophosphate]]. 1 ATP is consumed.  
 |- 
 | [[mevalonate-5-pyrophosphate decarboxylase]] || style="background: light-dark(white,black)"| [[Image:Mdd2.jpg|class=skin-invert-image|center|400px]] || Mevalonate-5-pyrophosphate is decarboxylated to yield [[isopentenyl pyrophosphate]] (IPP). 1 ATP is consumed. 
 |- 
 | [[isopentenyl pyrophosphate isomerase]]   || style="background: light-dark(white,black)"| [[Image:IPP isomerase reaction.svg|class=skin-invert-image|center|400px]] || [[isopentenyl pyrophosphate]] is [[isomerized]] to [[dimethylallyl pyrophosphate]].
|}