Editing Molecular dynamics (section)

=== Generalized ensembles ===

The [[replica exchange]] method is a generalized ensemble. It was originally created to deal with the slow dynamics of disordered spin systems. It is also called parallel tempering. The replica exchange MD (REMD) formulation<ref>{{cite journal | vauthors = Sugita Y, Okamoto Y |title=Replica-exchange molecular dynamics method for protein folding |journal=Chemical Physics Letters |date=November 1999 |volume=314 |issue=1–2 |pages=141–151 |doi=10.1016/S0009-2614(99)01123-9 |bibcode= 1999CPL...314..141S }}</ref> tries to overcome the multiple-minima problem by exchanging the temperature of non-interacting replicas of the system running at several temperatures.