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Morning sickness
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===Medications=== A number of [[antiemetic]]s are effective and safe in pregnancy including: [[pyridoxine/doxylamine]], [[antihistamines]] (such as [[diphenhydramine]]), [[metoclopramide]], and [[phenothiazines]] (such as [[promethazine]]).<ref name="BMJ2011">{{cite journal |vauthors=Jarvis S, Nelson-Piercy C |date=June 2011 |title=Management of nausea and vomiting in pregnancy |url=https://www.bmj.com/content/342/bmj.d3606 |journal=[[The BMJ]] |type=Review <!-- from pubmed --> |volume=342 |pages=d3606 |doi=10.1136/bmj.d3606 |pmid=21685438 |s2cid=32242306 |url-access=subscription}}</ref><ref name="Clark2014"/> With respect to effectiveness it is unknown if one is superior to another.<ref name=BMJ2011/> In the United States and Canada, the doxylamine-pyridoxine combination (as Diclegis in US and Diclectin in Canada) is the only approved [[pregnancy category]] "A" prescription treatment for nausea and vomiting of pregnancy.<ref name="Clark2014">{{cite journal |vauthors=Clark SM, Dutta E, Hankins GD |date=December 2014 |title=The outpatient management and special considerations of nausea and vomiting in pregnancy |url=https://www.sciencedirect.com/science/article/abs/pii/S0146000514001025 |journal=[[Seminars in Perinatology]] |type=Review <!-- from Pubmed --> |volume=38 |issue=8 |pages=496β502 |doi=10.1053/j.semperi.2014.08.014 |pmid=25267280 |url-access=subscription}}</ref> [[Ondansetron]] may be beneficial, but there are some concerns regarding an association with [[cleft palate]],<ref>{{cite journal |vauthors=[[Gideon Koren|Koren G]] |date=October 2012 |title=Is ondansetron safe for use during pregnancy? |url=https://www.cfp.ca/content/58/10/1092 |department=Motherisk update |journal=[[Canadian Family Physician]] |volume=58 |issue=10 |pages=1092β1093 |doi=<!-- have not found for this article --> |pmc=3470505 |pmid=23064917 |url-access=}}</ref> and there is little high quality data.<ref name=BMJ2011/> [[Metoclopramide]] is also used and relatively well tolerated.<ref>{{cite journal |vauthors=Tan PC, Omar SZ |date=April 2011 |title=Contemporary approaches to hyperemesis during pregnancy |url=https://journals.lww.com/co-obgyn/abstract/2011/04000/contemporary_approaches_to_hyperemesis_during.6.aspx |department=Maternal-Fetal Medicine |journal=[[Current Opinion in Obstetrics & Gynecology]] |type=Review<!-- from pubmed --> |volume=23 |issue=2 |pages=87β93 |doi=10.1097/GCO.0b013e328342d208 |pmid=21297474 |s2cid=11743580 |url-access=subscription}}</ref> Evidence for the use of [[corticosteroid]]s is weak.<ref>{{cite journal |vauthors=Poon SL |date=October 2011 |title=BET 2: Steroid therapy in the treatment of intractable hyperemesis gravidarum |url=https://emj.bmj.com/content/28/10/898.3 |department=Best Evidence Topic reports |journal=[[Emergency Medicine Journal]] |type=Review <!-- from pubmed --> |volume=28 |issue=10 |pages=898β900 |doi=10.1136/emermed-2011-200636 |pmid=21918097 |s2cid=6667779 |url-access=subscription}}</ref>
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