Editing Nociceptor (section)

===Chemical===
Chemical nociceptors have TRP channels that respond to a wide variety of spices. The one that sees the most response and is very widely tested is [[capsaicin]]. Other chemical stimulants are environmental irritants like [[acrolein]], a [[World War I]] [[chemical weapon]] and a component of cigarette smoke. Apart from these external stimulants, chemical nociceptors have the capacity to detect endogenous ligands, and certain fatty acid amines that arise from changes in internal tissues. Like in thermal nociceptors, TRPV1 can detect chemicals like capsaicin and spider toxins and acids.<ref name = Woolf/><ref name="Ganong 2019">{{cite book|title=Ganong's Review of Medical Physiology|year=2019|isbn=978-1-260-12240-4|last1=Yuan|first1=Jason|last2=Brooks|first2=Heddwen L.|last3=Barman|first3=Susan M.|last4=Barrett|first4=Kim E.|publisher=McGraw-Hill Education }}</ref> [[Acid-sensing ion channel|Acid-sensing ion channels (ASIC)]] also detect acidity.<ref name="Ganong 2019"/>