Editing Nuclear Overhauser effect (section)

== Some experimental methods ==
Some examples of one and two-dimensional NMR experimental techniques exploiting the NOE include:

* NOESY, Nuclear Overhauser effect Spectroscopy
* HOESY, Heteronuclear Overhauser effect spectroscopy
* ROESY, Rotational frame nuclear Overhauser effect spectroscopy
* TRNOE, Transferred nuclear Overhauser effect
* DPFGSE-NOE, Double pulsed field gradient spin echo NOE experiment

NOESY is the determination of the relative orientations of atoms in a molecule, for example a protein or other large biological molecule, producing a three-dimensional structure. HOESY is NOESY cross-correlation between atoms of different elements. ROESY involves spin-locking the magnetization to prevent it from going to zero, applied for molecules for which regular NOESY is not applicable. TRNOE measures the NOE between two different molecules interacting in the same solution, as in a ligand binding to a protein.<ref name="NiScheraga1994">{{cite journal|last1=Ni|first1=Feng|last2=Scheraga|first2=Harold A.|year=1994|title=Use of the Transferred Nuclear Overhauser Effect To Determine the Conformations of Ligands Bound to Proteins|journal=Accounts of Chemical Research|volume=27|issue=9|pages=257–264|doi=10.1021/ar00045a001|issn=0001-4842}}</ref> In a DPFGSE-NOE experiment, a transient experiment that allows for suppression of strong signals and thus detection of very small NOEs.