Editing Parietal cell (section)

==Clinical significance==
[[File:GASTRIC PARIETAL CELL ANTIBODIES.jpg|thumb|[[Immunofluorescence]] staining pattern of gastric parietal antibodies on a stomach section]]
[[File:Histopathology of fundic gland polyp, high magnification, annotated.jpg|thumb|Parietal cells are part of [[fundic gland polyp]]s (here shown in high magnification).<ref name=PathologyOutlines-fundic-gland>{{cite web|url=https://www.pathologyoutlines.com/topic/stomachfundicgland.html|title=Stomach Polyps - Fundic gland polyp|website=PathologyOutlines|author=Naziheh Assarzadegan, M.D., Raul S. Gonzalez, M.D.}} Topic Completed: 1 November 2017. Minor changes: 11 December 2019</ref>]]
* ''[[Peptic ulcer]]s'' can result from over-acidity in the stomach. Antacids can be used to enhance the natural tolerance of the gastric lining. [[Antimuscarinic]] drugs such as [[pirenzepine]] or H<sub>2</sub> [[antihistamine]]s can reduce acid secretion. [[Proton pump inhibitor]]s are more potent at reducing gastric acid production since that is the final common pathway of all stimulation of acid production.
* In ''[[pernicious anemia]]'', [[autoantibody|autoantibodies]] directed against parietal cells or intrinsic factor cause a reduction in vitamin B<sub>12</sub> absorption. It can be treated with injections of replacement vitamin B<sub>12</sub> ([[methylcobalamin]], [[hydroxocobalamin]] or [[cyanocobalamin]]).
* ''[[Achlorhydria]]'' is another [[autoimmune]] disease of the parietal cells. The damaged parietal cells are unable to produce the required amount of gastric acid. This leads to an increase in gastric pH, impaired digestion of food and increased risk of [[gastroenteritis]].