Editing Plasma cell (section)

==Clinical significance==
[[Plasmacytoma]], [[multiple myeloma]], [[Waldenström macroglobulinemia]], [[heavy chain disease]], and [[plasma cell leukemia]] are [[cancer]]s of the plasma cells.<ref>{{DorlandsDict|nine/000951264|Plasma cell}}</ref> Multiple myeloma is frequently identified because malignant plasma cells continue producing an antibody, which can be detected as a [[paraprotein]]. [[Monoclonal gammopathy of undetermined significance|Monoclonal gammopathy of undetermined significance (MGUS)]] is a plasma cell dyscrasia characterized by the secretion of a myeloma protein into the blood and may lead to multiple myeloma.<ref>{{Cite journal |last1=Agarwal |first1=Amit |last2=Ghobrial |first2=Irene M. |date=2013-03-01 |title=Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma: a review of the current understanding of epidemiology, biology, risk stratification, and management of myeloma precursor disease |journal=Clinical Cancer Research|volume=19 |issue=5 |pages=985–994 |doi=10.1158/1078-0432.CCR-12-2922 |issn=1557-3265 |pmc=3593941 |pmid=23224402}}</ref>

[[Common variable immunodeficiency]] is thought to be due to a problem in the [[cellular differentiation|differentiation]] from lymphocytes to plasma cells. The result is a low serum antibody level and risk of infections.{{cn|date=May 2024}}

[[AL amyloidosis|Primary amyloidosis (AL)]] is caused by the deposition of excess immunoglobulin light chains which are secreted from plasma cells.{{cn|date=May 2024}}