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Pleiotropy
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=== Spurious pleiotropy === Sometimes, what looks like pleiotropy can be caused by problems in how the study is designed or how risk genes and traits are defined, leading to incorrect conclusions about pleiotropy. Spurious pleiotropy occures when there is a misclassification either at the genomic level or the phenotypic level. At the genomic level, this might happen when a region of the [[genome]] linked to a special trait includes causal variants that are related. When this is the case, variants that influence different phenotypes through separate biological mechanisms may wrongly appear as a single pleiotropic locus. <ref name=":1" />
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