Editing Propranolol (section)

==Adverse effects==
{{See also|Beta blocker#Adverse effects}}

Propranolol should be used with caution in people with:<ref name="Rossi">{{cite book | veditors = Rossi S | title = [[Australian Medicines Handbook]] | date = 2006 | location = Adelaide | publisher = Australian Medicines Handbook }}</ref>
* [[Diabetes mellitus]] or [[hyperthyroidism]], since signs and symptoms of [[hypoglycemia]] may be masked
* [[Peripheral artery disease]] and [[Raynaud's syndrome|Raynaud syndrome]], which may be exacerbated
* [[Phaeochromocytoma]], as [[hypertension]] may be aggravated without prior [[alpha blocker]] therapy
* [[Myasthenia gravis]], which may be worsened
* Other drugs with [[bradycardia|bradycardic]] effects

===Pregnancy and lactation===
Propranolol, like other beta-blockers, is classified as [[pregnancy category]] C in the United States and [[Australian Drug Evaluation Committee|ADEC]] category C in Australia. β-blocking agents in general reduce perfusion of the [[placenta]], which may lead to adverse outcomes for the [[neonate]], including [[human lung|lung]] or [[human heart|heart]] complications, or [[premature birth]]. The newborn may experience additional adverse effects such as [[hypoglycemia|low blood sugar]] and a [[bradycardia|slower than normal heart rate]].<ref name="Martindale">{{Cite book| veditors = Sweetman SC |chapter=Cardiovascular Drugs|title=Martindale: The complete drug reference |edition=36th |year=2009|pages=1226–1381|publisher=Pharmaceutical Press |location=London|isbn=978-0-85369-840-1|title-link=Martindale: The complete drug reference}}</ref>

Most β-blocking agents appear in the milk of [[lactation|lactating]] women. However, propranolol is highly [[plasma protein binding|bound to proteins in the bloodstream]] and is distributed into breast milk at very low levels.<ref name="LactMed">[No authors listed] (2007). "Propranolol". In: ''Drugs and Lactation Database.'' U.S. [[National Library of Medicine]] Toxicology Data Network. Retrieved 25 February 2013.</ref> These low levels are not expected to pose any risk to the breastfeeding infant, and the [[American Academy of Pediatrics]] considers propranolol therapy "generally compatible with breastfeeding."<ref name="Martindale"/><ref name="LactMed"/><ref>{{cite journal |author=Committee on Drugs | title = Transfer of drugs and other chemicals into human milk | journal = Pediatrics | volume = 108 | issue = 3 | pages = 776–789 | date = September 2001 | pmid = 11533352 | doi = 10.1542/peds.108.3.776| s2cid = 27763768 | doi-access = free }}</ref><ref>{{cite journal | vauthors = Spencer JP, Gonzalez LS, Barnhart DJ | title = Medications in the breast-feeding mother | journal = American Family Physician | volume = 64 | issue = 1 | pages = 119–126 | date = July 2001 | pmid = 11456429 }}</ref>