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Prostate
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===In ejaculation=== The prostate secretes fluid, which becomes part of the [[semen]]. Its secretion forms up to 30% of the semen. Semen is the fluid emitted ([[ejaculated]]) through the male [[urethra]] during the [[sexual stimulation|sexual response]].<ref name="Barrett-2019" /> Sperm are emitted from the [[vas deferens]] into the male urethra via the [[ejaculatory duct]], which lies within the prostate gland.<ref name="Barrett-2019" /> Semen is moved into the urethra following contractions of the smooth muscle of the vas deferens and seminal vesicles, following stimulation, primarily of the [[glans penis]]. Stimulation sends nerve signals via the [[internal pudendal nerve]]s to the upper [[lumbar spine]]; the nerve signals causing contraction act via the [[hypogastric nerve]]s.<ref name="Barrett-2019" /> After traveling into the urethra, the seminal fluid is ejaculated by contraction of the [[bulbocavernosus muscle]].<ref name="Barrett-2019">{{Cite book |last1=Barrett |first1=Kim E. |title=Ganong's review of medical physiology |last2=Barman |first2=Susan M. |last3=Brooks |first3=Heddwen L. |last4=Yuan |first4=Jason X.-J. |last5=Ganong |first5=William F. |publisher=McGraw-Hill Education |year=2019 |isbn=9781260122404 |edition=26th |location=New York |pages=411, 415 |oclc=1076268769}}</ref> The secretions of the prostate include [[proteolytic enzyme]]s, [[prostatic acid phosphatase]], [[fibrinolysin]], [[zinc]], and [[prostate-specific antigen]].<ref name="Standring-2016" /> Together with the secretions from the seminal vesicles, these form the major fluid part of semen.<ref name="Standring-2016" /> The prostate contains various metals, including zinc,<ref>{{cite journal|last1 = Zaichick | first1 = Sofia | last2 = Zaichick | first2 = Vladimir | date = 2012| title = Mass fractions of 52 trace elements and zinc/trace element content ratios in intact human prostates investigated by inductively coupled plasma mass spectrometry | url = https://link.springer.com/article/10.1007/s12011-012-9427-4 | journal = Biol Trace Elem Res | volume = 149 | issue = 2 | pages = 171β183 | doi = 10.1007/s12011-012-9427-4 | pmid = 22549701| bibcode = 2012BTER..149..171Z | access-date =2024-12-27| url-access = subscription }}</ref> and is known to be the primary source of most metals found in semen, which are released during ejaculation.<ref>{{cite journal | last1 = Tanaka | first1 = Takazo | last2 = Kojo | first2 = Kosuke | date = 2024 | title = A new clustering model based on the seminal plasma/serum ratios of multiple trace element concentrations in male patients with subfertility | journal = Reprod Med Biol | volume = 23 | issue = 1 | pages = e12584 | doi = 10.1002/rmb2.12584 | pmc = 11131575 | pmid = 38807752 }}</ref>
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