Editing Reserpine (section)

==Research==
===Animal model of depression and amotivation===
Similarly to [[tetrabenazine]], reserpine, via [[monoamine depleting agent|depletion of monoamine neurotransmitters]], produces [[depression (mood)|depression]]-like effects and lack of [[motivation]] or [[fatigue (medical)|fatigue]]-like symptoms in animals.<ref name="StutzGolaniWitkin2019">{{cite journal | vauthors = Stutz PV, Golani LK, Witkin JM | title = Animal models of fatigue in major depressive disorder | journal = Physiol Behav | volume = 199 | issue = | pages = 300–305 | date = February 2019 | pmid = 30513290 | doi = 10.1016/j.physbeh.2018.11.042 | url = | quote = In a study performed by Sommer et al. (2014), healthy rats treated with the selective dopamine transport (DAT) inhibitor MRZ-9547 (Fig. 1) chose high effort, high reward more often than their untreated matched controls.}}</ref><ref name="SalamoneYohnLópez-Cruz2016">{{cite journal | vauthors = Salamone JD, Yohn SE, López-Cruz L, San Miguel N, Correa M | title = Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology | journal = Brain | volume = 139 | issue = Pt 5 | pages = 1325–1347 | date = May 2016 | pmid = 27189581 | pmc = 5839596 | doi = 10.1093/brain/aww050 | url = | quote = Several recent studies have focused on the effort-related effects of [tetrabenazine (TBZ)]. TBZ inhibits VMAT-2 (i.e. vesicular monoamine transporter type 2, encoded by Slc18a2), which results in reduced vesicular storage and depletion of monoamines. The greatest effects of TBZ at low doses have been reported to be on dopamine in the striatal complex, which is substantially depleted relative to norepinephrine and 5- HT (Pettibone et al., 1984; Tanra et al., 1995). Originally developed as a reserpine-type antipsychotic, TBZ has been approved for use as a treatment for Huntington’s disease and other movement disorders, but its major side effects include depressive symptoms (Frank, 2009, 2010; Guay, 2010; Chen et al., 2012). Like reserpine, TBZ has been used in studies involving classical animal models of depression (Preskorn et al., 1984; Kent et al., 1986; Wang et al., 2010). Low doses of TBZ that decreased accumbens dopamine release and dopamine-related signal transduction altered effort-related choice behaviour as assessed by concurrent lever pressing/chow feeding choice procedures (Nunes et al., 2013b; Randall et al., 2014).}}</ref> This can be useful in evaluating new [[antidepressant]]s and [[psychostimulant]]-like agents.<ref name="StutzGolaniWitkin2019" /><ref name="SalamoneYohnLópez-Cruz2016" />

===Antibacterial effects===
Reserpine inhibits formation of biofilms by ''Staphylococcus aureus'' and inhibits the metabolic activity of bacteria present in biofilms.<ref>{{cite journal | vauthors = Parai D, Banerjee M, Dey P, Mukherjee SK | title = Reserpine attenuates biofilm formation and virulence of Staphylococcus aureus | journal = Microbial Pathogenesis | volume = 138 | pages = 103790 | date = January 2020 | pmid = 31605761 | doi = 10.1016/j.micpath.2019.103790 | doi-access =  }}</ref>