Editing Sumatriptan (section)

==== Metabolism ====
Sumatriptan is metabolised primarily by [[Monoamine oxidase|monoamine oxidase A]] into indol-3-yl-acetaldehyde and then into corresponding carboxylic acid. It is further modified by [[Glucuronosyltransferase|UDP-glucuronosyltransferase]] into a conjugate with [[glucuronic acid]]. Other pathways are mediated by [[Cytochrome P450 (individual enzymes)|cytochrome P450 isoenzymes]], which give an [[Amine oxide|''N''-oxide]] derivative, and ''N''-desmethyl and ''N,N''-didesmethyl forms (the latter can be converted into the aldehyde by monoamine oxidase A). ''N''-desmethyl derivative can also undergo a reaction with [[Cysteine|<small>D</small>-cysteine]].<ref name="Pöstges_2023">{{cite journal | vauthors = Pöstges T, Lehr M | title = Metabolism of sumatriptan revisited | journal = Pharmacology Research & Perspectives | volume = 11 | issue = 1 | pages = e01051 | date = February 2023 | pmid = 36655303 | pmc = 9849828 | doi = 10.1002/prp2.1051 }}</ref>

These metabolites are excreted in the urine and bile. Only about 3% of the active drug may be recovered unchanged.<ref name="AHFS2019" />
[[File:Sumatriptan metabolism pathway.png|center|thumb|881x881px|Sumatriptan metabolic pathways (MAO-A – monoamine oxidase A, CYP - cytochrome P450 isoenzymes)<ref name="Pöstges_2023" />]]