Editing Transferrin (section)

== Transferrin and nanomedicine ==
Many drugs are hindered when providing treatment when crossing the blood-brain barrier yielding poor uptake into areas of the brain. Transferrin glycoproteins are able to bypass the [[Blood–brain barrier|blood-brain barrier]] via receptor-mediated transport for specific transferrin receptors found in the brain capillary endothelial cells.<ref>{{cite journal | vauthors = Ghadiri M, Vasheghani-Farahani E, Atyabi F, Kobarfard F, Mohamadyar-Toupkanlou F, Hosseinkhani H | title = Transferrin-conjugated magnetic dextran-spermine nanoparticles for targeted drug transport across blood-brain barrier | journal = Journal of Biomedical Materials Research Part A | volume = 105 | issue = 10 | pages = 2851–2864 | date = October 2017 | pmid = 28639394 | doi = 10.1002/jbm.a.36145 }}</ref> Due to this functionality, it is theorized that [[Nanoparticles for drug delivery to the brain|nanoparticles]] acting as drug carriers bound to transferrin glycoproteins can penetrate the blood-brain barrier allowing these substances to reach the diseased cells in the brain.<ref>{{cite journal | vauthors = Gaspar R | title = Nanoparticles: Pushed off target with proteins | journal = Nature Nanotechnology | volume = 8 | issue = 2 | pages = 79–80 | date = February 2013 | pmid = 23380930 | doi = 10.1038/nnano.2013.11 | bibcode = 2013NatNa...8...79G }}</ref> Advances with transferrin conjugated nanoparticles can lead to non-invasive drug distribution in the brain with potential therapeutic consequences of [[central nervous system]] (CNS) targeted diseases (e.g. [[Alzheimer's disease|Alzheimer's]] or [[Parkinson's disease|Parkinson's]] disease).<ref>{{cite journal | vauthors = Li S, Peng Z, Dallman J, Baker J, Othman AM, Blackwelder PL, Leblanc RM | title = Crossing the blood-brain-barrier with transferrin conjugated carbon dots: A zebrafish model study | journal = Colloids and Surfaces B: Biointerfaces | volume = 145 | pages = 251–256 | date = September 2016 | pmid = 27187189 | doi = 10.1016/j.colsurfb.2016.05.007 | doi-access = free }}</ref>