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Transient receptor potential channel
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===TRPP=== {| class="wikitable" !Family !Sub-Family<ref name="Peng" /><ref name="Montell_2001" /><ref name="Gallio_Brivido">{{cite journal | vauthors = Gallio M, Ofstad TA, Macpherson LJ, Wang JW, Zuker CS | title = The coding of temperature in the Drosophila brain | journal = Cell | volume = 144 | issue = 4 | pages = 614–24 | date = February 2011 | pmid = 21335241 | pmc = 3336488 | doi = 10.1016/j.cell.2011.01.028 | doi-access = free }}</ref><ref name="TRP_review">{{cite journal | vauthors = Himmel NJ, Cox DN | title = Transient receptor potential channels: current perspectives on evolution, structure, function and nomenclature | journal = Proceedings. Biological Sciences | volume = 287 | issue = 1933 | pages = 20201309 | date = August 2020 | pmid = 32842926 | pmc = 7482286 | doi = 10.1098/rspb.2020.1309 | doi-access = free }}</ref> !Known Taxa<ref name="BC 2018">{{cite journal | vauthors = Bezares-Calderón LA, Berger J, Jasek S, Verasztó C, Mendes S, Gühmann M, Almeda R, Shahidi R, Jékely G | display-authors = 6 | title = Neural circuitry of a polycystin-mediated hydrodynamic startle response for predator avoidance | journal = eLife | volume = 7 | date = December 2018 | pmid = 30547885 | pmc = 6294549 | doi = 10.7554/eLife.36262 | doi-access = free }}</ref><ref name="Gallio_Brivido" /> |- |rowspan="3" |TRPP |PKD1-like |Animals (excluding arthropods) |- |PKD2-like |Animals |- |Brividos |Insects |} [[TRPP]], P for "polycistin", is named for [[Autosomal dominant polycystic kidney disease|polycystic kidney disease]], which is associated with these channels.<ref name=":4" /> These channels are also referred to as PKD (polycistic kidney disease) ion channels. PKD2-like genes (examples include [[TRPP2]], [[TRPP3]], and [[TRPP5]]) encode canonical TRP channels. PKD1-like genes encode much larger proteins with 11 transmembrane segments, which do not have all the features of other TRP channels. However, 6 of the transmebrane segments of PKD1-like proteins have substantial sequence homology with TRP channels, indicating they may simply have diversified greatly from other closely related proteins.<ref name="BC 2018" /> Insects have a third sub-family of TRPP, called brividos, which participate in cold sensing.<ref name="Gallio_Brivido" /><ref name="TRP_review" />
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