Editing Triptan (section)

==Contraindications==
All triptans are contraindicated in patients with [[cardiovascular disease]]s ([[coronary spasm]]s, symptomatic [[coronary artery disease]], after a [[heart attack]] or [[stroke]], uncontrolled [[hypertension]], [[Raynaud's disease]], [[peripheral artery disease]]).<ref>{{cite journal |last1=Dodick |first1=David W. |last2=Shewale |first2=Anand S. |last3=Lipton |first3=Richard B. |last4=Baum |first4=Seth J. |last5=Marcus |first5=Steven C. |last6=Silberstein |first6=Stephen D. |last7=Pavlovic |first7=Jelena M. |last8=Bennett |first8=Nathan L. |last9=Young |first9=William B. |last10=Viswanathan |first10=Hema N. |last11=Doshi |first11=Jalpa A. |last12=Weintraub |first12=Howard |title=Migraine Patients With Cardiovascular Disease and Contraindications: An Analysis of Real-World Claims Data |journal=Journal of Primary Care & Community Health |date=January 2020 |volume=11 |doi=10.1177/2150132720963680 |pmid=33095099 |pmc=7585888 }}</ref><ref>{{cite journal |last1=Tepper |first1=Stewart J. |last2=Spears |first2=Roderick C. |title=Acute Treatment of Migraine |journal=Neurologic Clinics |date=May 2009 |volume=27 |issue=2 |pages=417–427 |doi=10.1016/j.ncl.2008.11.008 |pmid=19289223 }}</ref> Most triptans are also contraindicated during pregnancy and breastfeeding and for patients younger than 18; but sumatriptan and zolmitriptan nasal sprays are also approved for youths over 12.<ref name="Mutschler" /> In spite of expert opinion and evidence to the contrary, the FDA and some other drug governance bodies have stated that [[monoamine oxidase inhibitor]]s are contraindicated for sumatriptan, zolmitriptan and rizatriptan,<ref name="Ferrari" /><ref name="Goodman" /> and combination with [[ergot alkaloid]]s such as [[ergotamine]] for all substances.<ref name="AC" />

At least two triptans (sumatriptan and rizatriptan) have been listed under the unacceptable medication by the [[Canadian Blood Services]] as a potential risk to the recipient; hence, donors are required not to have taken the medication for the last 72 hours.<ref>{{Cite journal |last1=Gawde |first1=Prathamesh |last2=Shah |first2=Harsh |last3=Patel |first3=Harsh |last4=Bharathi |first4=Koppineedi S |last5=Patel |first5=Neil |last6=Sethi |first6=Yashendra |last7=Kaka |first7=Nirja |title=Revisiting Migraine: The Evolving Pathophysiology and the Expanding Management Armamentarium |journal=Cureus |date=2023 |volume=15 |issue=2 |pages=e34553 |doi=10.7759/cureus.34553 |doi-access=free |issn=2168-8184 |pmc=9985459 |pmid=36879707}}</ref>