Editing Acetophenone (section)

== Pharmacology ==
In the late 19th and early 20th centuries, acetophenone was used in medicine.<ref>{{Merck12th}}</ref> It was marketed as a [[hypnotic]] and [[anticonvulsant]] under brand name Hypnone. The typical dosage was 0.12 to 0.3 milliliters.<ref>{{cite book | last= Bartholow|first= Roberts | title = A Practical Treatise on Materia Medica and Therapeutics | publisher = Appleton & Co | date = 1908}}</ref> It was considered to have superior sedative effects to both [[paraldehyde]] and [[chloral hydrate]].<ref>{{cite journal|last=Norman|first=Conolly|title=Cases illustrating the sedative effects of aceto-phenone|journal=Journal of Mental Science|volume=32|page=519|date=1887|doi=10.1192/bjp.32.140.519}}</ref> In humans, acetophenone is metabolized to [[benzoic acid]], [[carbonic acid]], and [[acetone]].<ref>{{cite journal | title = Hypnone – The new hypnotic | journal = Journal of the American Medical Association | volume = 5 | page = 632 | date = 1885 | issue = 23 | doi = 10.1001/jama.1885.02391220016006}}</ref> [[Hippuric acid]] occurs as an indirect metabolite and its quantity in urine may be used to confirm acetophenone exposure,<ref name=pubchem>{{PubChem|7410}}</ref> although other substances, like toluene, also induce hippuric acid in urine.<ref>{{cite web|url=http://www.beroepsziekten.nl/datafiles/A044.pdf|title=The Netherlands Center for Occupational Diseases (NCvB): toluene (Dutch)|website=beroepsziekten.nl|access-date=19 April 2018}}</ref>